The distribution of amphotericin B in lung tissue was studied in 18 patients with primary or secondary lung cancer who underwent thoracotomy and pulmonary resection. At different times before surgery the patients were treated with liposomal amphotericin B 1.5 mg/kg by i.v. infusion over 1h. Blood and lung tissue samples were collected during surgery (one subjects for each collecting time) and assayed for amphotericin B levels by HPLC. Due to surgical requirements, it was possible to obtain data from the 10th to the 25th h after the end of infusion. Plasma amphotericin B concentrations progressively decreased from 3.4 mcg/ml at the 10th h to 1 mcg/ml at the 25th h after the end of intravenous infusion. In lung tissue samples the lowest amphotericin B concentration (about 1 mcg/g) was observed at the 10th h, then a progressive increase was observed with the highest value (2.5 mcg/g) determined at the 25th h.

Penetration of amphotericin B in human lung tissue after single liposomal amphotericin B (AmBisome) infusion / G. Demartini, C. Lequaglie, P. P. Brega Massone, F. Scaglione, F. Fraschini. - In: JOURNAL OF CHEMOTHERAPY. - ISSN 1120-009X. - 17:1(2005 Feb), pp. 82-85.

Penetration of amphotericin B in human lung tissue after single liposomal amphotericin B (AmBisome) infusion

G. Demartini
Primo
;
F. Scaglione
Penultimo
;
F. Fraschini
Ultimo
2005

Abstract

The distribution of amphotericin B in lung tissue was studied in 18 patients with primary or secondary lung cancer who underwent thoracotomy and pulmonary resection. At different times before surgery the patients were treated with liposomal amphotericin B 1.5 mg/kg by i.v. infusion over 1h. Blood and lung tissue samples were collected during surgery (one subjects for each collecting time) and assayed for amphotericin B levels by HPLC. Due to surgical requirements, it was possible to obtain data from the 10th to the 25th h after the end of infusion. Plasma amphotericin B concentrations progressively decreased from 3.4 mcg/ml at the 10th h to 1 mcg/ml at the 25th h after the end of intravenous infusion. In lung tissue samples the lowest amphotericin B concentration (about 1 mcg/g) was observed at the 10th h, then a progressive increase was observed with the highest value (2.5 mcg/g) determined at the 25th h.
Humans; Liposomal amphotericin B; Lung tissue distribution
Settore BIO/14 - Farmacologia
feb-2005
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/5656
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 17
  • ???jsp.display-item.citation.isi??? 15
social impact