Background The main objective of regenerative periodontal therapy is to completely restore the periodontal tissues lost. This review summarizes the most recent evidence in support of scaffold- and cell-based tissue engineering, which are expected to play a relevant role in next-generation periodontal regenerative therapy. Methods A literature search (PubMed database) was performed to analyze more recently updated articles regarding periodontal regeneration, scaffolds and cell-based technologies. Results Evidence supports the importance of scaffold physical cues to promote periodontal regeneration, including scaffold multicompartmentalization and micropatterning. The in situ delivery of biological mediators and/or cell populations, both stem cells and already differentiated cells, has shown promising in vivo efficacy. Conclusions Porous scaffolds are pivotal for clot stabilization, wound compartmentalization, cell homing and cell nutrients delivery. Given the revolutionary introduction of rapid prototyping technique and cell-based therapies, the fabrication of custom-made scaffolds is not far from being achieved.

Engineered scaffolds and cell-based therapy for periodontal regeneration / D. Carmagnola, M. Tarce, C. Dellavia, L. Rimondini, E.M. Varoni. - In: JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS. - ISSN 2280-8000. - 15:4(2017 Dec), pp. e303-e312.

Engineered scaffolds and cell-based therapy for periodontal regeneration

D. Carmagnola
Primo
;
C. Dellavia;E.M. Varoni
Ultimo
2017

Abstract

Background The main objective of regenerative periodontal therapy is to completely restore the periodontal tissues lost. This review summarizes the most recent evidence in support of scaffold- and cell-based tissue engineering, which are expected to play a relevant role in next-generation periodontal regenerative therapy. Methods A literature search (PubMed database) was performed to analyze more recently updated articles regarding periodontal regeneration, scaffolds and cell-based technologies. Results Evidence supports the importance of scaffold physical cues to promote periodontal regeneration, including scaffold multicompartmentalization and micropatterning. The in situ delivery of biological mediators and/or cell populations, both stem cells and already differentiated cells, has shown promising in vivo efficacy. Conclusions Porous scaffolds are pivotal for clot stabilization, wound compartmentalization, cell homing and cell nutrients delivery. Given the revolutionary introduction of rapid prototyping technique and cell-based therapies, the fabrication of custom-made scaffolds is not far from being achieved.
calcium phosphates; cell encapsulation; cell sheet technology; Chitosan; multilayered scaffolds; regenerative periodontal therapy; cell culture techniques; cell- and tissue-based therapy; humans; periodontal diseases; periodontium; regeneration; regenerative medicine; tissue engineering; tissue scaffolds; biophysics; bioengineering; biomaterials; biomedical engineering
Settore MED/28 - Malattie Odontostomatologiche
dic-2017
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/562572
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