BACKGROUND: Long-lasting erythematous lesions involving the balanopreputial sac may be clinically difficult to classify, and biopsies may be performed in order to clarify the nature of the disease. However, our previous experience led us to consider several cases as histopathologically unclassifiable. OBJECTIVE: To establish the causes of such unsatisfactory findings. METHODS: We reviewed 120 balanopreputial sac biopsies performed at the surgical unit of our institute from January 1999 to December 2002 examining also the patients' clinical records. RESULTS: We found that a small group of previously unclassified cases showed common clinical and histopathological features. Clinically, all patients were uncircumcised and had long-lasting asymptomatic erythematous plaques on the balanopreputial sac with no erythroplastic or lichenoid features and no correlation with sexual intercourse. Histologically, all specimens showed a thinned and spongiotic epithelium, a band-like infiltrate of lymphocytes and histiocytes with a variable number of plasma cells in the upper part of the chorion and further signs of acute, subacute or chronic inflammation. CONCLUSIONS: In our view, these cases fall within a spectrum of inflammatory non-cicatricial disorders, ranging from almost pure lymphohistiocytic forms to forms which fulfil all criteria to be classified as balanitis circumscripta plasmacellularis of Zoon. We propose to classify these cases histologically as inflammatory non-cicatricial balanoposthitis and clinically as idiopathic inflammatory non-cicatricial balanoposthitis.
|Titolo:||Review of 120 biopsies performed on the balanopreputial sac. From Zoon's balanitis to the concept of a wider spectrum of inflammatory non-cicatricial balanoposthitis|
|Autori interni:||ALESSI, ELVIO GIUSEPPE ANGELO (Primo)|
GIANOTTI, RAFFAELE (Ultimo)
|Parole Chiave:||balanitis, balanoposthitis, Zoon's balanitis, inflammatory non-cicatricial balanoposthitis, idiopathic inflammatory non-cicatricial balanoposthitis|
|Settore Scientifico Disciplinare:||Settore MED/35 - Malattie Cutanee e Veneree|
|Data di pubblicazione:||2004|
|Digital Object Identifier (DOI):||10.1159/000076484|
|Appare nelle tipologie:||01 - Articolo su periodico|
File in questo prodotto:
- PubMed Central loading...