DNA topological transitions occur when replication forks encounter other DNA transactions such as transcription. Failure in resolving such conflicts leads to generation of aberrant replication and transcription intermediates that might have adverse effects on genome stability. Cells have evolved numerous surveillance mechanisms to avoid, tolerate, and resolve such replication-transcription conflicts. Defects or non-coordination in such cellular mechanisms might have catastrophic effect on cell viability. In this chapter, we review consequences of replication encounters with transcription and its associated events, topological challenges, and how these inevitable conflicts alter the genome structure and functions.
Coordinating replication with transcription / Y.J. Achar, M. Foiani (ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY). - In: DNA Replication : From Old Principles to New Discoveries / [a cura di] H. Masai, M. Foiani. - [s.l] : Springer, 2018 Jan 23. - ISBN 9789811069543. - pp. 455-487 [10.1007/978-981-10-6955-0_20]
Coordinating replication with transcription
M. Foiani
2018
Abstract
DNA topological transitions occur when replication forks encounter other DNA transactions such as transcription. Failure in resolving such conflicts leads to generation of aberrant replication and transcription intermediates that might have adverse effects on genome stability. Cells have evolved numerous surveillance mechanisms to avoid, tolerate, and resolve such replication-transcription conflicts. Defects or non-coordination in such cellular mechanisms might have catastrophic effect on cell viability. In this chapter, we review consequences of replication encounters with transcription and its associated events, topological challenges, and how these inevitable conflicts alter the genome structure and functions.File | Dimensione | Formato | |
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