The purpose of this prospective randomised clinical study was to compare the efficacy of recombinant bone morphogenetic protein 7 (rhBMP-7) and platelet-rich plasma (PRP) as bone-stimulating agents in the treatment of persistent fracture non-unions. One hundred and twenty patients were randomised into two treatment groups (group rhBMP-7 vs. group PRP). Sixty patients with sixty fracture non-unions were assigned to each group (median age: 44 years, range 19-65, for the rhBMP-7 group and 41 years, range 21-62, for the PRP group, respectively). In the rhBMP-7 group, there were 15 tibial non-unions, 10 femoral, 15 humeral, 12 ulnar, and 8 radial non-unions. In the PRP group, there were 19 tibial non-unions, 8 femoral, 16 humeral, 8 ulnar, and 9 radial non-unions. The median number of operations performed prior to our intervention was 2 (range 1-5) and 2 (range 1-5) with autologous bone graft being used in 23 and 21 cases for the rhBMP-7 and PRP groups, respectively. Both clinical and radiological union occurred in 52 (86.7%) cases of the rhBMP-7 group compared to 41 (68.3%) cases of the PRP group, with a lower median clinical and radiographic healing time observed in the rhBMP-7 group (3.5 months vs. 4 months and 8 months vs. 9 months, respectively). This study supports the view that in the treatment of persistent long bone non-unions, the application of rhBMP-7 as a bone-stimulating agent is superior compared to that of PRP with regard to their clinical and radiological efficacy.
Application of rhBMP-7 and platelet-rich plasma in the treatment of long bone non-unions : a prospective randomised clinical study on 120 patients / G.M. Calori, L. Tagliabue, L. Gala, M. d’Imporzano, G. Peretti, W. Albisetti. - In: INJURY. - ISSN 0020-1383. - 39:12(2008 Dec), pp. 1391-1402.
|Titolo:||Application of rhBMP-7 and platelet-rich plasma in the treatment of long bone non-unions : a prospective randomised clinical study on 120 patients|
TAGLIABUE, LORENZO (Secondo)
PERETTI, GIOVANNI (Penultimo)
ALBISETTI, WALTER (Ultimo)
|Parole Chiave:||rhBMP-7 ; PRP ; long bones ; non-union ; bone healing|
|Settore Scientifico Disciplinare:||Settore MED/33 - Malattie Apparato Locomotore|
Settore MED/34 - Medicina Fisica e Riabilitativa
|Data di pubblicazione:||dic-2008|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.injury.2008.08.011|
|Appare nelle tipologie:||01 - Articolo su periodico|
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