Recent studies have demonstrated that in mice, the estrogen receptor alpha (ERα) is expressed in the liver and has a direct effect on the regulation of the hepatic genes relevant for energy metabolism and drug metabolism. The sex-related differential expression of the hepatic ERα raises the questions as to whether this receptor is responsible for the sexual differences observed in the physiopathology of the liver.
Sexual dimorphism and estrogen action in mouse liver / S.D. Torre, F. Lolli, P. Ciana, A. Maggi (ADVANCES IN INTERNAL MEDICINE). - In: Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity / [a cura di] F. Mauvais-Jarvis. - [s.l] : Springer, 2017 Dec 10. - ISBN 9783319701776. - pp. 141-151
Sexual dimorphism and estrogen action in mouse liver
S.D. Torre;F. Lolli;P. Ciana;A. Maggi
2017
Abstract
Recent studies have demonstrated that in mice, the estrogen receptor alpha (ERα) is expressed in the liver and has a direct effect on the regulation of the hepatic genes relevant for energy metabolism and drug metabolism. The sex-related differential expression of the hepatic ERα raises the questions as to whether this receptor is responsible for the sexual differences observed in the physiopathology of the liver.
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