Objective: The aim of this study was to compare, in normotensive postmenopausal women, the effects of drospirenone/estradiol and norethisterone acetate/estradiol on blood pressure and other surrogate markers of cerebrovascular and cardiovascular risk. Methods: Thirty postmenopausal women were submitted to utero-ovarian ultrasonography and to color Doppler evaluation of ophthalmic arteries. Ultrasonographic and Doppler analysis of brachial artery flow-mediated vasodilatation and 24-hour ambulatory blood pressure monitoring were performed. Plasma concentrations of nitrites/nitrates were assayed. The participants were randomly assigned to drospirenone 2 mg/estradiol 1 mg (group 1; n = 15) or norethisterone acetate 0.5 mg/estradiol 1 mg (group 2; n = 15) treatment. The duration of the study was 6 months. Results: The basal pulsatility index and the back pressure of the ophthalmic artery were similar in groups 1 and 2. After 6 months, no changes were observed. The nitrites/nitrates values were not different between groups 1 and 2 both in basal conditions and after therapy. The brachial artery flow-mediated vasodilatation and the pulsatility index of the brachial artery did not show any difference in groups 1 and 2 both in basal conditions and after the therapy. The 24-hour blood pressure monitoring showed no significant differences in the 24-hour time, daytime, and nighttime values either in basal conditions or after therapy. All participants were found to be dippers normally (nocturnal reduction 10% in comparison with diurnal values). The wake-up blood pressure values were similar in the studied participants. Conclusions: A 6-month hormone therapy with drospirenone/estradiol or norethisterone acetate/estradiol is equally effective and does not seem to alter the surrogate markers of cardiovascular and cerebrovascular risk.
Angeliq versus Activelle in normotensive postmenopausal women: a prospective, randomized pilot study / C. Battaglia, A. Cianciosi, F. Mancini, N. Persico, G. Sisti, F. Facchinetti, P. Busacchi. - In: MENOPAUSE. - ISSN 1072-3714. - 16:4(2009), pp. 803-809.
|Titolo:||Angeliq versus Activelle in normotensive postmenopausal women: a prospective, randomized pilot study|
|Parole Chiave:||Androstenes; Blood Pressure; Brachial Artery; Cardiovascular Diseases; Cardiovascular System; Cerebrovascular Circulation; Cerebrovascular Disorders; Drug Combinations; Estradiol; Female; Humans; Middle Aged; Norethindrone; Ophthalmic Artery; Ovary; Pilot Projects; Prospective Studies; Pulsatile Flow; Risk Factors; Ultrasonography; Uterus; Vasodilation; Postmenopause|
|Settore Scientifico Disciplinare:||Settore MED/40 - Ginecologia e Ostetricia|
|Data di pubblicazione:||2009|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/gme.0b013e3181963ef4|
|Appare nelle tipologie:||01 - Articolo su periodico|