Stress is a primary risk factor for neuropsychiatric disorders; at times, even a single trauma can trigger psychopathology. Many rodent models of neuropsychiatric disorders use chronic stress, measuring readouts at the end of long protocols. In a way, traditional chronic models overlook a crucial question: how does the physiological response to stressor(s) turn into a maladaptive pathway that may verge towards psychopathology? Recent evidence suggests that studying the long-term consequences of acute stress would provide critical information on the role of stress in psychopathology. This new conceptual framework could enable us to understand the determinants of a pro-adaptive versus maladaptive trajectory of stress response, and also to study the mechanism of rapid-acting antidepressants, such as ketamine, that target the glutamate system directly.
Acute or Chronic? A Stressful Question / L. Musazzi, P. Tornese, N. Sala, M. Popoli. - In: TRENDS IN NEUROSCIENCES. - ISSN 0166-2236. - 40:9(2017), pp. 525-535.
|Titolo:||Acute or Chronic? A Stressful Question|
POPOLI, MAURIZIO (Corresponding)
|Parole Chiave:||corticosterone; glutamate; ketamine; psychopathology; resilience; stress; Acute Disease; Animals; Chronic Disease; Humans; Stress, Psychological; Neuroscience (all)|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.tins.2017.07.002|
|Appare nelle tipologie:||01 - Articolo su periodico|