Despite remarkable successes in the treatment of breast cancer, some challenges remain. Gold nanoparticles may prove valuable in addressing these problems owing to their unique characteristics that make them elective agents for the conjugation with drugs and for photothermal therapy . The potential toxicity of AuNPs remains a major hurdle that impedes their use in clinical settings. In this study, stable and biocompatible colloidal AuNPs (4-10 nm) were obtained by their functionalization with biocompatible stabilizing polymers (polyamidoamines, PAA). Sequentially, coated-AuNPs were used as platform for the conjugation of anticancer drugs (Fig. 1). AuNPs were conjugated with Herceptin, a chemotherapic agent used to treat breast cancer and their efficacy was evaluated in vitro. Two breast cancer cell lines were used (SKBR-3 and MCF-7) and compared with fibroblast-like cell line (NIH-3T3). Preliminary biological investigation showed that polymer coated-AuNPs functionalized with Herceptin led to increased efficacy and specificity for target cells in comparison with free drug and uncoated AuNPs, consistent with the endocytosis capability of the nanoparticles in the target cancer cells.
Gold nanoparticles decorated with polyamidoamines for the delivery of anticancer drugs: synthesis and biological characterization / N. Bloise, C. DELLA PINA, A. Massironi, F. Bertoglio, M. Rossi, A.G. Manfredi, P. Ferruti, E. Ranucci, L. Visai - In: Proceedings of the Milan Polymer Days congressPrima edizione. - Ebook. - [s.l] : Edises, 2018 Feb 14. - ISBN 978887958712. - pp. 85-85 (( convegno Milan Polymer Days tenutosi a Milano nel 2018.
|Titolo:||Gold nanoparticles decorated with polyamidoamines for the delivery of anticancer drugs: synthesis and biological characterization|
|Settore Scientifico Disciplinare:||Settore CHIM/04 - Chimica Industriale|
|Data di pubblicazione:||14-feb-2018|
|Enti collegati al convegno:||Università degli Studi di Milano|
Società Chimica Italiana
Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali
|Tipologia:||Book Part (author)|
|Appare nelle tipologie:||03 - Contributo in volume|