Two hundred and forty household contacts of 85 chronic HBsAg carriers were studied to assess the relationship between liver histology and 'e' antigen or antibody positivity in the index carrier, and evidence of HBV infection within the family. Liver biopsy results were available in 54 index carriers. The prevalence of HBsAg and anti-HBs in the families of 29 carriers with chronic hepatitis and 25 carriers with either a normal liver or minimal inflammatory changes was not significantly different. Serum from 72 index carriers was available for HBeAg and anti-HBe testing. The prevalence of HBsAg and anti-HBs in the families of 5 HBeAg positive carriers, 59 anti-HBs positive subjects, and 8 carriers negative for both HBeAg and anti-HBe was again not significantly different. Infectivity of a carrier thus does not appear to correlate either with histological evidence of liver damage or with the 'e' antigen or antibody positivity of the carrier.

Intrafamilial spread of hepatitis B virus infection : Role of chronic hepatitis and of the hepatitis B e antigen / R. de Franchis, A. D'Arminio, F. Viganò, M. Vecchi, M.G. Rumi, G. Ronchi, M. Primignani, E. Del Ninno. - In: LA RICERCA IN CLINICA E IN LABORATORIO. - ISSN 0390-5748. - 11:2(1981), pp. 151-158.

Intrafamilial spread of hepatitis B virus infection : Role of chronic hepatitis and of the hepatitis B e antigen

A. D'Arminio;M.G. Rumi;
1981

Abstract

Two hundred and forty household contacts of 85 chronic HBsAg carriers were studied to assess the relationship between liver histology and 'e' antigen or antibody positivity in the index carrier, and evidence of HBV infection within the family. Liver biopsy results were available in 54 index carriers. The prevalence of HBsAg and anti-HBs in the families of 29 carriers with chronic hepatitis and 25 carriers with either a normal liver or minimal inflammatory changes was not significantly different. Serum from 72 index carriers was available for HBeAg and anti-HBe testing. The prevalence of HBsAg and anti-HBs in the families of 5 HBeAg positive carriers, 59 anti-HBs positive subjects, and 8 carriers negative for both HBeAg and anti-HBe was again not significantly different. Infectivity of a carrier thus does not appear to correlate either with histological evidence of liver damage or with the 'e' antigen or antibody positivity of the carrier.
Adult; Biopsy; Chronic Disease; Female; Hepatitis B; Humans; Liver; Male; Carrier State; Hepatitis B Antigens; Hepatitis B Surface Antigens; Hepatitis B e Antigens
Settore MED/17 - Malattie Infettive
1981
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/557288
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