Fifty-three parenteral drug-addicts with acute viral hepatitis type B were tested by a solid-phase radioimmunoassay for circulating HBsAg/IgM complexes in the acute phase and in the follow-up. Among the 47 recovered patients HBsAg/IgM complexes were either absent from the onset of the disease, or disappeared from serum within 4 weeks of admission, long before HBsAg had cleared or serum alanine aminotransferase has returned to normal. On the contrary, HBsAg/IgM complexes persisted indefinitely among the 6 patients who developed a chronic HBsAg-positive hepatitis. These results indicate that sequential serum testing for HBsAg/IgM complexes might be of value in predicting the long-term outcome of acute type B hepatitis of parenteral drug-addicts.

Acute type B hepatitis in parenteral drug-addicts (PDA): prognostic value of circulating HBsAg/IgM complexes / F. Caredda, R. De Franchis, A. D'Arminio Monforte, M. Vecchi, F. Antoniozzi, E. Rossi, M. Primignani, M. Moroni. - In: BOLLETTINO DELL'ISTITUTO SIEROTERAPICO MILANESE. - ISSN 0021-2547. - 63:6(1984), pp. 496-498.

Acute type B hepatitis in parenteral drug-addicts (PDA): prognostic value of circulating HBsAg/IgM complexes

R. De Franchis;A. D'Arminio Monforte;M. Moroni
1984

Abstract

Fifty-three parenteral drug-addicts with acute viral hepatitis type B were tested by a solid-phase radioimmunoassay for circulating HBsAg/IgM complexes in the acute phase and in the follow-up. Among the 47 recovered patients HBsAg/IgM complexes were either absent from the onset of the disease, or disappeared from serum within 4 weeks of admission, long before HBsAg had cleared or serum alanine aminotransferase has returned to normal. On the contrary, HBsAg/IgM complexes persisted indefinitely among the 6 patients who developed a chronic HBsAg-positive hepatitis. These results indicate that sequential serum testing for HBsAg/IgM complexes might be of value in predicting the long-term outcome of acute type B hepatitis of parenteral drug-addicts.
Acute Disease; Adolescent; Adult; Antigen-Antibody Complex; Female; Hepatitis B; Hepatitis B Surface Antigens; Humans; Immunoglobulin M; Injections, Intravenous; Male; Prognosis; Radioimmunoassay; Substance-Related Disorders
Settore MED/17 - Malattie Infettive
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/557261
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