Economic decision-making is disrupted in individuals with gambling disorder, an addictive behavior observed in Parkinsonâs disease (PD) patients receiving dopaminergic therapy. The subthalamic nucleus (STN) is involved in the inhibition of impulsive behaviors; however, its role in impulse control disorders and addiction is still unclear. Here, we recorded STN local field potentials (LFPs) in PD patients with and without gambling disorder during an economic decision-making task. Reaction times analysis showed that for all patients, the decision whether to risk preceded task onset. We compared then for both groups the STN LFP preceding high- and low-risk economic decisions. We found that risk avoidance in gamblers correlated with larger STN LFP low-frequency (<12-Hz) fluctuations preceding task onset. In particular, the amplitude of low-frequency LFP fluctuations carried significant information about future decisions. Decisions of patients not affected by gambling disorder were instead not correlated with pretask STN LFP. Our results suggest that STN activity preceding task onset affects risk decisions by preemptively inhibiting attraction to high but unlikely rewards in favor of a long-term payoff.
Subthalamic neural activity patterns anticipate economic risk decisions in gambling / A. Mazzoni, M. Rosa, J. Carpaneto, L.M. Romito, A. Priori, S. Micera. - In: ENEURO. - ISSN 2373-2822. - 5:1(2018 Feb 06), pp. UNSP e0366-17.2017.1-UNSP e0366-17.2017.17. [10.1523/ENEURO.0366-17.2017]
Subthalamic neural activity patterns anticipate economic risk decisions in gambling
A. PrioriPenultimo
;
2018
Abstract
Economic decision-making is disrupted in individuals with gambling disorder, an addictive behavior observed in Parkinsonâs disease (PD) patients receiving dopaminergic therapy. The subthalamic nucleus (STN) is involved in the inhibition of impulsive behaviors; however, its role in impulse control disorders and addiction is still unclear. Here, we recorded STN local field potentials (LFPs) in PD patients with and without gambling disorder during an economic decision-making task. Reaction times analysis showed that for all patients, the decision whether to risk preceded task onset. We compared then for both groups the STN LFP preceding high- and low-risk economic decisions. We found that risk avoidance in gamblers correlated with larger STN LFP low-frequency (<12-Hz) fluctuations preceding task onset. In particular, the amplitude of low-frequency LFP fluctuations carried significant information about future decisions. Decisions of patients not affected by gambling disorder were instead not correlated with pretask STN LFP. Our results suggest that STN activity preceding task onset affects risk decisions by preemptively inhibiting attraction to high but unlikely rewards in favor of a long-term payoff.File | Dimensione | Formato | |
---|---|---|---|
Mazzoni2018.pdf
accesso aperto
Tipologia:
Publisher's version/PDF
Dimensione
2.67 MB
Formato
Adobe PDF
|
2.67 MB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.