We report two cases of louse-borne relapsing fever observed at our Institution in June 2016. Both patients were young asylum seekers from Africa who had recently arrived in Milan, Italy. Notably, direct microscopic examination of peripheral blood smears was repeatedly negative for the presence of spirochetes and the diagnosis, supported by clinical and epidemiologic evidence, required molecular confirmation by polymerase chain reaction amplification of DNA extracted from blood and sequencing of the amplified products.

Diagnosis of louse-borne relapsing fever despite negative microscopy in two asylum seekers from Eastern Africa / S. Antinori, C. Tonello, S. Edouard, C. Parravicini, D. Gastaldi, R. Grande, L. Milazzo, D. Ricaboni, F. Fenollar, D. Raoult, M. Corbellino, O. Mediannikov. - In: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. - ISSN 0002-9637. - 97:6(2017 Dec), pp. 1669-1672. [10.4269/ajtmh.17-0320]

Diagnosis of louse-borne relapsing fever despite negative microscopy in two asylum seekers from Eastern Africa

S. Antinori
Writing – Review & Editing
;
C. Tonello
Investigation
;
D. Ricaboni;
2017-12

Abstract

We report two cases of louse-borne relapsing fever observed at our Institution in June 2016. Both patients were young asylum seekers from Africa who had recently arrived in Milan, Italy. Notably, direct microscopic examination of peripheral blood smears was repeatedly negative for the presence of spirochetes and the diagnosis, supported by clinical and epidemiologic evidence, required molecular confirmation by polymerase chain reaction amplification of DNA extracted from blood and sequencing of the amplified products.
Adult; Anti-Bacterial Agents; Borrelia; DNA, Bacterial; Doxycycline; Humans; Italy; Male; Microscopy; Polymerase Chain Reaction; Refugees; Relapsing Fever; Somalia; Sudan; Parasitology; Infectious Diseases; Virology
Settore MED/17 - Malattie Infettive
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/556647
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