Purpose: To analyze the role of polymerase chain reaction (PCR) of ocular fluids in management of tubercular (TB) anterior, intermediate, posterior, and panuveitis. Methods: In Collaborative Ocular Tuberculosis Study (COTS)-1 (25 centers, n = 962), patients with TB-related uveitis were included. 59 patients undergoing PCR of intraocular fluids (18 females; 53 Asian Indians) were included. Results: 59 (6.13%) of COTS-1 underwent PCR analysis. PCR was positive for Mycobacterium TB in 33 patients (23 males; all Asian Indians). 26 patients were PCR negative (18 males). Eight patients with negative PCR had systemic TB. Anti-TB therapy was given in 18 negative and 31 PCR cases. At 1-year follow-up, five patients with positive PCR (15.15%) and three with negative PCR (11.54%) had persistence/worsening of inflammation. Conclusions: Data from COTS-1 suggest that PCR is not commonly done for diagnosing intraocular TB and positive/negative results may not influence management or treatment outcomes in the real world scenario.
The Collaborative Ocular Tuberculosis Study (COTS)-1 Report 3: Polymerase Chain Reaction in the Diagnosis and Management of Tubercular Uveitis: Global Trends / A. Agarwal, R. Agrawal, D.V. Gunasekaran, D. Raje, B. Gupta, K. Aggarwal, S.L. Murthy, M. Westcott, S.P. Chee, P. Mccluskey, H. Su Ling, S. Teoh, L. Cimino, J. Biswas, S. Narain, M. Agarwal, P. Mahendradas, M. Khairallah, N. Jones, I. Tugal-Tutkun, K. Babu, S. Basu, E. Carreño, R. Lee, H. Al-Dhibi, B. Bodaghi, A. Invernizzi, D.A. Goldstein, C.P. Herbort, T. Barisani-Asenbauer, J.J. González-López, S. Androudi, R. Bansal, B. Moharana, S. Mahajan, S. Esposti, A. Tasiopoulou, S. Nadarajah, M. Agarwal, S. Abraham, R. Vala, R. Singh, A. Sharma, K. Sharma, M. Zierhut, O.M. Kon, E. Cunningham, Q.D. Nguyen, C. Pavesio, V. Gupta. - In: OCULAR IMMUNOLOGY AND INFLAMMATION. - ISSN 0927-3948. - (2018), pp. 1-9. [Epub ahead of print] [10.1080/09273948.2017.1406529]
The Collaborative Ocular Tuberculosis Study (COTS)-1 Report 3: Polymerase Chain Reaction in the Diagnosis and Management of Tubercular Uveitis: Global Trends
A. Invernizzi;
2018
Abstract
Purpose: To analyze the role of polymerase chain reaction (PCR) of ocular fluids in management of tubercular (TB) anterior, intermediate, posterior, and panuveitis. Methods: In Collaborative Ocular Tuberculosis Study (COTS)-1 (25 centers, n = 962), patients with TB-related uveitis were included. 59 patients undergoing PCR of intraocular fluids (18 females; 53 Asian Indians) were included. Results: 59 (6.13%) of COTS-1 underwent PCR analysis. PCR was positive for Mycobacterium TB in 33 patients (23 males; all Asian Indians). 26 patients were PCR negative (18 males). Eight patients with negative PCR had systemic TB. Anti-TB therapy was given in 18 negative and 31 PCR cases. At 1-year follow-up, five patients with positive PCR (15.15%) and three with negative PCR (11.54%) had persistence/worsening of inflammation. Conclusions: Data from COTS-1 suggest that PCR is not commonly done for diagnosing intraocular TB and positive/negative results may not influence management or treatment outcomes in the real world scenario.
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