Purpose: To describe multiple evanescent white dot syndrome (MEWDS)-related foveal granularity features on different imaging modalities. Methods: Clinical and multi-imaging files from five patients affected by MEWDS were reviewed. Each image set included: blue fundus autofluorescence (BAF), near-infrared fundus autofluorescence (NIR-FAF), spectral-domain optical coherence tomography (SD-OCT), fluorescein (FA), and indocyanine green (ICGA) angiography. Foveal granularity features were analyzed and described for each technique at baseline and follow-up. Results: At baseline, 4/5 patients did not show white dots at funduscopic examination, but all subjects demonstrated hypo-fluorescent lesions on ICGA and areas of increased BAF. In all patients, foveal granularity was detectable on NIR-FAF as an irregular hypo-fluorescent area, persisting during follow-up visits. The corresponding SD-OCT scans revealed outer retinal layers’ disruption resolving overtime. Conclusions: Foveal granularity can be the sole presenting sign of MEWDS. NIR-FAF and SD-OCT should be considered as non-invasive investigations in the detection of MEWDS-related foveal granularity.

Multiple Evanescent White Dot Syndrome: A Multimodal Imaging Study of Foveal Granularity / A. Mantovani, A. Invernizzi, G. Staurenghi, C.P. Herbort. - In: OCULAR IMMUNOLOGY AND INFLAMMATION. - ISSN 0927-3948. - (2017). [Epub ahead of print] [10.1080/09273948.2017.1353104]

Multiple Evanescent White Dot Syndrome: A Multimodal Imaging Study of Foveal Granularity

A. Mantovani;A. Invernizzi
Secondo
;
G. Staurenghi;
2017

Abstract

Purpose: To describe multiple evanescent white dot syndrome (MEWDS)-related foveal granularity features on different imaging modalities. Methods: Clinical and multi-imaging files from five patients affected by MEWDS were reviewed. Each image set included: blue fundus autofluorescence (BAF), near-infrared fundus autofluorescence (NIR-FAF), spectral-domain optical coherence tomography (SD-OCT), fluorescein (FA), and indocyanine green (ICGA) angiography. Foveal granularity features were analyzed and described for each technique at baseline and follow-up. Results: At baseline, 4/5 patients did not show white dots at funduscopic examination, but all subjects demonstrated hypo-fluorescent lesions on ICGA and areas of increased BAF. In all patients, foveal granularity was detectable on NIR-FAF as an irregular hypo-fluorescent area, persisting during follow-up visits. The corresponding SD-OCT scans revealed outer retinal layers’ disruption resolving overtime. Conclusions: Foveal granularity can be the sole presenting sign of MEWDS. NIR-FAF and SD-OCT should be considered as non-invasive investigations in the detection of MEWDS-related foveal granularity.
Autofluorescence; fovea granularity; MEWDS; optical coherence tomography; uveitis; Immunology and Allergy; Ophthalmology
Settore MED/30 - Malattie Apparato Visivo
2017
2017
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/555664
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