The use of radionuclides plays a crucial role in Nuclear Medicine in the areas of diagnostics, of metabolic radiotherapy and of theranostics. To produce each non-conventional radionuclide it is necessary to point out a protocol that provides the optimization of production with high specific activity of the radionuclide of interest, typically through the use of charged-particle accelerators, the development of appropriate radiochemical separations and of a strict quality control system of the product obtained. We will present the case of Zr-89, one of the most promising radionuclide for labelling monoclonal antibodies, bio-distribution studies and immuno-PET imaging.
Optimization of the production of non-conventional high specific activity radionuclides for medicine / S. Manenti, F. Groppi. ((Intervento presentato al 103. convegno Congresso Nazionale della Società Italiana di Fisica tenutosi a Trento nel 2017.
Optimization of the production of non-conventional high specific activity radionuclides for medicine
S. Manenti
Primo
;F. GroppiUltimo
2017
Abstract
The use of radionuclides plays a crucial role in Nuclear Medicine in the areas of diagnostics, of metabolic radiotherapy and of theranostics. To produce each non-conventional radionuclide it is necessary to point out a protocol that provides the optimization of production with high specific activity of the radionuclide of interest, typically through the use of charged-particle accelerators, the development of appropriate radiochemical separations and of a strict quality control system of the product obtained. We will present the case of Zr-89, one of the most promising radionuclide for labelling monoclonal antibodies, bio-distribution studies and immuno-PET imaging.Pubblicazioni consigliate
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