Combined quantitative (real-time) polymerase chain reaction and immunohistochemistry were used to evaluate the expression of the minor acute phase protein alpha 1-acid glycoprotein (AGP, orosomucoid) in bovine extrahepatic tissues. AGP was produced mainly in the salivary glands and spleen, whereas minor expression was detected in all other tissues sampled, including lung, lymph nodes, uterus, ovary, kidney and tongue. The findings were consistent with immunohistochemical results. In view of the immunomodulatory and direct antibacterial activity of AGP, its expression in the salivary glands may signal an involvement in the regulation of the local immunity, even in non-pathological conditions.

Extra hepatic expression of the acute phase protein alpha 1-acid glycoprotein in normal bovine tissues / C. Lecchi, G. Avallone, M. Giurovich, P. Roccabianca, F. Ceciliani. - In: THE VETERINARY JOURNAL. - ISSN 1090-0233. - 180:2(2009 May), pp. 256-258. [10.1016/j.tvjl.2007.12.027]

Extra hepatic expression of the acute phase protein alpha 1-acid glycoprotein in normal bovine tissues

C. Lecchi
Primo
;
G. Avallone
Secondo
;
P. Roccabianca
Penultimo
;
F. Ceciliani
Ultimo
2009

Abstract

Combined quantitative (real-time) polymerase chain reaction and immunohistochemistry were used to evaluate the expression of the minor acute phase protein alpha 1-acid glycoprotein (AGP, orosomucoid) in bovine extrahepatic tissues. AGP was produced mainly in the salivary glands and spleen, whereas minor expression was detected in all other tissues sampled, including lung, lymph nodes, uterus, ovary, kidney and tongue. The findings were consistent with immunohistochemical results. In view of the immunomodulatory and direct antibacterial activity of AGP, its expression in the salivary glands may signal an involvement in the regulation of the local immunity, even in non-pathological conditions.
Acute phase protein; Alpha 1-acid glycoprotein; Bovine; PCR
Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria
mag-2009
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/55394
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