The deletion (5q) karyotype (del [5q]) in patients with myelodysplastic syndrome (MDS) is the most common karyotypic abnormality in de novo MDS. An increased number of blasts and additional karyotypic abnormalities (del [5q]+) are associated with a poor outcome. We analyzed the outcome of allogeneic hematopoietic cell transplants (HCT) in patients suffering from MDS with only del (5q) or del (5q)+. A total of 162 patients, of median age 54 years (range, 9 to 73), having MDS and del (5q) abnormalities received HCT from identical siblings (n = 87) or unrelated donors (n = 75). The cumulative incidence of nonrelapse mortality and relapse incidence at 4 years was 29% (95% CI, 22 to 36) and 46% (95% CI, 38 to 54), whereas the estimated 4 year survival, relapse-free and overall, was 25% (95% CI, 18 to 33) and 30% (95% CI, 23 to 38), respectively. In a multivariate analysis patients with del (5q) and a blast excess displayed poorer survival (hazard ratio, 2.38; 95% CI, 1.44 to 3.93; P < .001), whereas female recipient sex resulted in improved survival (hazard ratio, .61; 95% CI, .41 to .90; P = .01). We conclude that allogeneic HCT can cure a subset of patients with MDS and a del (5q) abnormality.
Allogeneic Stem Cell Transplantation for Myelodysplastic Syndrome Patients with a 5q Deletion / L. Garderet, D. Ziagkos, A. van Biezen, S. Iacobelli, J. Finke, J. Maertens, L. Volin, P. Ljungman, P. Chevallier, J. Passweg, N. Schaap, D. Beelen, A. Nagler, D. Blaise, X. Poiré, I. Yakoub-Agha, S. Lenhoff, C. Craddock, R. Schots, A. Rambaldi, J. Sanz, P. Jindra, G.J. Mufti, M. Robin, N. Kröger. - In: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. - ISSN 1083-8791. - 24:3(2018), pp. 507-513.
|Titolo:||Allogeneic Stem Cell Transplantation for Myelodysplastic Syndrome Patients with a 5q Deletion|
|Parole Chiave:||Allogeneic stem cell transplantation; Del (5q); MDS; Hematology; Transplantation|
|Settore Scientifico Disciplinare:||Settore MED/15 - Malattie del Sangue|
|Data di pubblicazione:||2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.bbmt.2017.11.017|
|Appare nelle tipologie:||01 - Articolo su periodico|