Objectives: This phase II trial was aimed at assessing the safety and activity of capecitabine, oxaliplatin, and irinotecan (COI regimen) as a preoperative treatment for resectable gastric cancer (GC) or gastroesophageal junction (GEJ) cancer. Methods: Patients affected by T3-T4/N0-N+/M0 GC/GEJ cancer were treated with the COI regimen for 4 cycles followed by restaging and gastroresection with D2 lymphadenectomy. Four postoperative cycles were scheduled. The primary endpoint was pathological response rate according to Becker et al. [Cancer 2003;98:1521-1530]. The potential role of fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) as a predictive biomarker of pathological tumor response was assessed in a subgroup of 19 evaluable patients. Results: Between January 2011 and October 2015, a total of 40 patients were enrolled. After the preoperative phase, 36 out of 40 patients (90%) were considered eligible for surgery: 12 patients (30%) achieved a pathological response. The most frequent grade 3/4 adverse events were diarrhea (27%), nausea (25%), and fatigue (17%). Grade 3 neutropenia occurred in 7.5% of patients. A lower standard uptake value at baseline FDG-PET/CT was associated with pathological response. Conclusion: COI combination is active with a manageable toxicity profile in patients with resectable GC or GEJ cancer. FDG-PET/CT imaging as a surrogate biomarker of pathological response in this setting appears fascinating but should be further investigated.
Preoperative Capecitabine, Oxaliplatin, and Irinotecan in Resectable Gastric or Gastroesophageal Junction Cancer: Pathological Response as Primary Endpoint and FDG-PET Predictions / R. Berenato, F. Morano, F. Pietrantonio, C. Cotsoglou, M. Caporale, G. Infante, A. Pellegrinelli, A. Alessi, C. Battiston, J. Coppa, B. Padovano, A. Mennitto, M. Niger, G. Fucà, S. Lazzati, G. Greco, G. Delconte, F. De Braud, V. Mazzaferro, M. Di Bartolomeo. - In: ONCOLOGY. - ISSN 0030-2414. - 93:5(2017 Sep), pp. 279-286.
|Titolo:||Preoperative Capecitabine, Oxaliplatin, and Irinotecan in Resectable Gastric or Gastroesophageal Junction Cancer: Pathological Response as Primary Endpoint and FDG-PET Predictions|
|Parole Chiave:||Capecitabine; Combination chemotherapy; FDG-PET/CT; Gastric cancer; Irinotecan; Neoadjuvant chemotherapy; Oxaliplatin; Pathological response; Phase II study; Oncology; Cancer Research|
|Settore Scientifico Disciplinare:||Settore MED/06 - Oncologia Medica|
|Data di pubblicazione:||set-2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1159/000479154|
|Appare nelle tipologie:||01 - Articolo su periodico|