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IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishHuman polyomaviruses (HPyVs) asymptomatically infect the human population establishing latency in the host, and their seroprevalence can reach 90% in healthy adults. Few studies have focused on the pediatric population, and there are no reports regarding the seroprevalence of all the newly isolated HPyVs among Italian children. Therefore, we investigated the frequency of serum antibodies against 12 PyVs in 182 immunocompetent children from Northeast Italy, by means of a multiplex antibody detection system. Additionally, secondary lymphoid tissues were collected to analyze the presence of HPyV DNA sequences using a specific real-time PCRs or PCRs. Almost 100% of subjects were seropositive for at least one PyV. Seropositivity ranged from 3% for antibodies against simian virus 40 (SV40) in children from 0 to 3 years, to 91% for antibodies against WU polyomavirus (WUPyV) and HPyV10 in children from 8 to 17 years. The mean number of PyV for which children were seropositive increased with the increasing of age: 4 standard deviations (SD) 1.8 in the 0â3-year group, 5 (SD 1.9) in the 4â7-year group, and 6 (SD 2.2) in the 8â17-year group. JC polyomavirus (JCPyV) DNA was detected in 1% of the adenoids, WUPyV in 12% of the tonsils, and 28% of the adenoids, and Merkel cell polyomavirus (MCPyV) was present in 6 and 2% of the tonsils and adenoids, respectively. Our study gives new insights on the serological evidence of exposure to PyVs during childhood, and on their possible respiratory route of transmission.
Antibody response to polyomavirus primary infection: high seroprevalence of Merkel cell polyomavirus and lymphoid tissue involvement / C. Cason, L. Monasta, N. Zanotta, G. Campisciano, I. Maestri, M. Tommasino, M. Pawlita, S. Villani, M. Comar, S. Delbue. - In: JOURNAL OF NEUROVIROLOGY. - ISSN 1355-0284. - (2018). [Epub ahead of print]
| Titolo: | Antibody response to polyomavirus primary infection: high seroprevalence of Merkel cell polyomavirus and lymphoid tissue involvement |
| Autori: | |
| Parole Chiave: | Lymphoid tissues; MCPyV; Polyomaviruses; Seroprevalence; Neurology; Neurology (clinical); Cellular and Molecular Neuroscience; Virology |
| Settore Scientifico Disciplinare: | Settore MED/07 - Microbiologia e Microbiologia Clinica |
| Data di pubblicazione: | 2018 |
| Rivista: | |
| Tipologia: | Article (author) |
| Data ahead of print / Data di stampa: | 12-gen-2018 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s13365-017-0612-2 |
| Appare nelle tipologie: | 01 - Articolo su periodico |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| POLYOMAVIRUS REVISION 51217.pdf | Pre-print (manoscritto inviato all'editore) | Open Access Visualizza/Apri | ||
| 10.1007%2Fs13365-017-0612-2.pdf | Publisher's version/PDF | Administrator Richiedi una copia |
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