Aim: Merkel cell polyomavirus (MCPyV) is the etiological agent of Merkel cell carcinoma. Its genome has been detected in anatomic districts from healthy and ill subjects. Data regarding the MCPyV DNAemia in neurological patients are lacking. Materials & methods: Blood was obtained from 129 neurological patients and 181 controls (HIV positive or negative). Real-time polymerase chain reaction (Q-PCR) was conducted to quantify MCPyV loads in blood specimens. Results: MCPyV DNA was detected in 17.1% of cases and 11.0% of controls in <1% of cells. No association between MCPyV DNA presence and HIV status was observed. Conclusion: Blood cells may be a reservoir for MCPyV. The presence of MCPyV genome in blood of healthy subjects might be relevant for transfusion medicine.

Merkel cell polyomavirus DNA in the blood of patients with neurological diseases and healthy controls / L. Signorini, S. Villani, R. Ticozzi, F. Ambrogi, M. Dolci, R. Boldorini, M. Ciotti, P. Ferrante, S. Delbue. - In: FUTURE VIROLOGY. - ISSN 1746-0794. - 12:12(2017 Dec), pp. 713-720.

Merkel cell polyomavirus DNA in the blood of patients with neurological diseases and healthy controls

Signorini, Lucia;Villani, Sonia;Ticozzi, Rosalia;Ambrogi, Federico;Dolci, Maria;Ferrante, Pasquale;Delbue, Serena
2017-12

Abstract

Aim: Merkel cell polyomavirus (MCPyV) is the etiological agent of Merkel cell carcinoma. Its genome has been detected in anatomic districts from healthy and ill subjects. Data regarding the MCPyV DNAemia in neurological patients are lacking. Materials & methods: Blood was obtained from 129 neurological patients and 181 controls (HIV positive or negative). Real-time polymerase chain reaction (Q-PCR) was conducted to quantify MCPyV loads in blood specimens. Results: MCPyV DNA was detected in 17.1% of cases and 11.0% of controls in <1% of cells. No association between MCPyV DNA presence and HIV status was observed. Conclusion: Blood cells may be a reservoir for MCPyV. The presence of MCPyV genome in blood of healthy subjects might be relevant for transfusion medicine.
blood; Merkel cell polyomavirus; neurological diseases; virology
Settore MED/07 - Microbiologia e Microbiologia Clinica
FUTURE VIROLOGY
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/551550
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