Cow's milk allergy (CMA) is one of the most common food allergies, especially during childhood. CMA is an immunological mediated adverse reaction to one or more cow's milk proteins, which are normally harmless to a non-allergic individual, as the result of a failure of oral tolerance. To make a correct diagnosis of CMA and a proper treatment is critical in clinical practice. Application of proteomics along with new bio-informatics tools in the field of food allergy is one of the hot topics presented in recent years. In the present review, we focus on recent applications of proteomics to the field of cow's milk allergy, from allergens quantification to the diagnosis, treatment and prognosis. Furthermore, we also shed a light on potential future directions and developments, that are parts of personalized medicine but also of the One Health approach.

Precision medicine in cow's milk allergy: proteomics perspectives from allergens to patients / E. D'Auria, C. Mameli, C. Piras, L. Cococcioni, A. Urbani, G.V. Zuccotti, P. Roncada. - In: JOURNAL OF PROTEOMICS. - ISSN 1874-3919. - (2018 Feb 03). [Epub ahead of print]

Precision medicine in cow's milk allergy: proteomics perspectives from allergens to patients

E. D'Auria;C. Mameli;C. Piras;L. Cococcioni;G.V. Zuccotti;
2018-02-03

Abstract

Cow's milk allergy (CMA) is one of the most common food allergies, especially during childhood. CMA is an immunological mediated adverse reaction to one or more cow's milk proteins, which are normally harmless to a non-allergic individual, as the result of a failure of oral tolerance. To make a correct diagnosis of CMA and a proper treatment is critical in clinical practice. Application of proteomics along with new bio-informatics tools in the field of food allergy is one of the hot topics presented in recent years. In the present review, we focus on recent applications of proteomics to the field of cow's milk allergy, from allergens quantification to the diagnosis, treatment and prognosis. Furthermore, we also shed a light on potential future directions and developments, that are parts of personalized medicine but also of the One Health approach.
cow milk proteins; milk allergies; one health; personalized medicine; proteomics
Settore MED/38 - Pediatria Generale e Specialistica
Settore BIO/10 - Biochimica
Settore VET/05 - Malattie Infettive degli Animali Domestici
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/551396
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