Background: In the general population, low IGF1 has been associated with higher prevalence of cardiovascular disease and mortality. Objective: To investigate the relationships between IGF1 levels, blood pressure (BP), and glucose tolerance (GT). Subjects: Four-hundred and four subjects (200 men aged 18-80 years). Exclusion criteria: personal history of pituitary or cardiovascular diseases; previous or current treatments with drugs interfering with BP, GT, or lipids, corticosteroids (> 2 weeks), estrogens, or testosterone (> 12 weeks); smoking of > 15 cigarettes/day and alcohol abuse (> 3 glasses of wine/day). Results: Two hundred and ninety-six had normal BP (73.3%), 86 had mild (21.3%), and 22 had severe (5.4%) hypertension; 322 had normal GT (NGT (79.7%)), 53 had impaired glucose tolerance (IGT (13.1%)), 29 had diabetes mellitus (7.2%). Normotensive subjects had significantly higher IGF1 levels (0.11±0.94 SDS) than those with mild (-0.62±1.16 SDS, P<0.0001) or severe (-1.01±1.07 SDS, P<0.0001) hypertension. IGF1 SDS (t=-3.41, P=0.001) independently predicted systolic and diastolic BP (t=-2.77, P=0.006) values. NGT subjects had significantly higher IGF1 levels (0.13±0.90 SDS) than those with IGT (-0.86±1.14 SDS, P<0.0001) or diabetes mellitus (-1.31±1.13 SDS, P<0.0001). IGF1 SDS independently predicted fasting glucose (t=-3.49, P=0.0005) and homeostatic model assessment (HOMA)-R (t=-2.15, P=0.033) but not insulin (t=-1.92, P=0.055) and HOMA-β (t=-0.19, P=0.85). Conclusion: IGF1 levels in the low normal range are associated with hypertension and diabetes in subjects without pituitary and cardiovascular diseases.
|Titolo:||Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: an observational, exploratory study in 404 subjects|
|Autori interni:||VITALE, GIOVANNI|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
|Data di pubblicazione:||ott-2008|
|Digital Object Identifier (DOI):||10.1530/EJE-08-0201|
|Appare nelle tipologie:||01 - Articolo su periodico|