A patient with echinococcosis, acquired deficiency of the inhibitor of the activated first component of complement and angioedema symptoms has been studied. These symptoms started 7 months after the surgical removal of an echinococcus liver cyst. Eight years later, when the complement was investigated, a marked deficiency of the C1 inhibitor, C1, C4 and CH50 was present. The patient was therefore successfully treated with tranexamic acid. After 4 years, the woman needed another operation because of a relapse of echinococcosis; afterwards she was symptom-free without medications, while the complement profile remained unchanged. Circulating immune complexes were detected by the conglutinin method. The patient's serum was demonstrated to possess an anticomplementary activity without affecting the C1 inhibitor when incubated with normal human serum at 37 degrees C. At present, 16 years after the onset of the symptoms, there are no signs of lymphoproliferative disease.
Acquired C1 inhibitor deficiency with angioedema symptoms in a patient infected with Echinococcus granulosus / M. Cicardi, D. Frangi, L. Bergamaschini, M. Gardinali, G. Sacchi, A. Agostoni. - In: COMPLEMENT. - ISSN 0253-5076. - 2:2-3(1985), pp. 133-139.
|Titolo:||Acquired C1 inhibitor deficiency with angioedema symptoms in a patient infected with Echinococcus granulosus|
BERGAMASCHINI, LUIGI CESARE [Investigation]
|Parole Chiave:||Angioedema; Antigen-Antibody Complex; Complement C1 Inactivator Proteins; Echinococcosis, Hepatic; Female; Humans; Middle Aged|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||1985|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1159/000467853|
|Appare nelle tipologie:||01 - Articolo su periodico|