Background: Anemia represents a major risk factor for adverse health-related events in older persons. The aim of this study was to evaluate the association between hemoglobin levels/anemia and cognitive function in hospitalized older persons. Methods: Data are from the Gruppo Italiano di Farmacovigilanza nell'Anziano (GIFA) study. Hemoglobin levels (in g/dL) were measured upon admission to hospital; anemia was defined according to the WHO criteria. Cognitive performance was assessed by the Abbreviated Mental Test (AMT) on admission; an AMT score < 7 defined cognitive impairment. Logistic regressions and analyses of covariance were performed to evaluate the relationship between cognitive status and hemoglobin levels/ anemia. Results: Mean age of the sample (n = 13,301) was 72.0 years. Participants with cognitive impairment presented a higher prevalence of anemia (47%) compared to those without cognitive impairment (35%, p < 0.001). Adjusted logistic regressions showed that hemoglobin levels/ anemia were significantly associated with cognitive impairment (OR=0.96, 95%CI=0.94-0.99, p=0.004, and OR=1.32, 95%CI=1.18-1.48, p<0.001, respectively). Patients with anemia and cognitive impairment at the hospital admission presented a higher number of impaired Activities of Daily Living compared to those with only one or none of the studied conditions (p for trend < 0.001). Conclusions: Low hemoglobin levels and anemia are independently associated with cognitive performance in older persons admitted to acute care units.
Anemia and cognitive performance in hospitalized patients : results from the GIFA study / V. Zamboni, M. Cesari, G. Zuccalà, G. Onder, R.C. Woodman, C. Maraldi, M. Ranzini, S. Volpato, M. Pahor, R. Bernabei. - In: INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY. - ISSN 0885-6230. - 21:6(2006), pp. 529-534.
|Titolo:||Anemia and cognitive performance in hospitalized patients : results from the GIFA study|
|Parole Chiave:||Anemia; Cognitive function; Elderly; Epidemiology; Hemoglobin; Hospitalized patients; Activities of Daily Living; Aged; Aged, 80 and over; Anemia; Cognition Disorders; Epidemiologic Methods; Female; Geriatric Assessment; Hemoglobins; Hospitalization; Humans; Male; Middle Aged; Neuropsychological Tests; Geriatrics and Gerontology; Psychiatry and Mental Health|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||2006|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/gps.1520|
|Appare nelle tipologie:||01 - Articolo su periodico|
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