It is well known that the nephron endowment of healthy subjects is highly variable and that individual nephron mass has potentially important implications both in health and disease. However, nephron count is technically impossible in living subjects. Based on the observation of an increase in serum creatinine (sCr) in otherwise healthy newborns with solitary kidney during the physiological perinatal dehydration, we hypothesized that perinatal sCr might be helpful in identifying healthy subjects with a reduced nephron mass. In the framework of a study on blood pressure in babies (NeoNeph), sCr of normal Caucasian neonates was determined 48-96 h after birth and their association with a family history of arterial hypertension (AH) was analyzed. SCr was determined in 182 normal newborns (90 males) at a mean of 61 ± 8 h after birth (range 46-82). Newborns with paternal AH had a higher mean sCr (0.97 + 0.28 mg/dL) then newborns without paternal AH (0.73 + 0.28 mg/dL; p = 0.006). No differences in mean sCr were found in relation with mother or grandparent's history of AH.

Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment / G. Ardissino, F. Tel, I. Possenti, M. Pavesi, M. Perrone, G. Forni, P. Salice, L. Colombo, S. Ghirardello, B. Castiglione, D. Consonni, L. Baca, D.L. Vecchi, G. la Marca, F. Mosca. - In: EUROPEAN JOURNAL OF PEDIATRICS. - ISSN 0340-6199. - (2018 Feb 01). [Epub ahead of print] [10.1007/s00431-018-3087-0]

Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment

Gianluigi; Tel;Patrizia; Colombo;Dario; Baca;Giancarlo; Mosca
2018-02-01

Abstract

It is well known that the nephron endowment of healthy subjects is highly variable and that individual nephron mass has potentially important implications both in health and disease. However, nephron count is technically impossible in living subjects. Based on the observation of an increase in serum creatinine (sCr) in otherwise healthy newborns with solitary kidney during the physiological perinatal dehydration, we hypothesized that perinatal sCr might be helpful in identifying healthy subjects with a reduced nephron mass. In the framework of a study on blood pressure in babies (NeoNeph), sCr of normal Caucasian neonates was determined 48-96 h after birth and their association with a family history of arterial hypertension (AH) was analyzed. SCr was determined in 182 normal newborns (90 males) at a mean of 61 ± 8 h after birth (range 46-82). Newborns with paternal AH had a higher mean sCr (0.97 + 0.28 mg/dL) then newborns without paternal AH (0.73 + 0.28 mg/dL; p = 0.006). No differences in mean sCr were found in relation with mother or grandparent's history of AH.
Arterial hypertension; blood pressure; nephron endowment; newborn; perinatal serum creatinine
Settore MED/38 - Pediatria Generale e Specialistica
1-feb-2018
EUROPEAN JOURNAL OF PEDIATRICS
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/549028
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