Adenosine deaminase (ADA) catalyzes the deamination of 2',3'-isopropylidene adenosine and the corresponding 5'-amino derivative in a 3% dimethylsulfoxide aqueous solution. Whereas ADA is unable to convert other 5'-substituted derivatives (acetate, acetamido, azide), the enzyme adenylate deaminase (AMPDA) accepts all the above compounds as substrates for their biotransformation to the corresponding 5'-substituted inosine derivatives
Deamination of 5'-substituted-2',3'-isopropylidene adenosine derivatives catalyzed by adenosine deaminase (ADA, EC 3.5.4.4) and complementary enzymatic biotransformations catalyzed by adenylate deaminase (AMPDA, EC 3.5.4.6) : a viable route for the preparation of 5 '-substituted inosine derivatives / P. Ciuffreda, A. Loseto, E. Santaniello. - In: TETRAHEDRON. - ISSN 0040-4020. - 58:29(2002), pp. 5767-5771.
Deamination of 5'-substituted-2',3'-isopropylidene adenosine derivatives catalyzed by adenosine deaminase (ADA, EC 3.5.4.4) and complementary enzymatic biotransformations catalyzed by adenylate deaminase (AMPDA, EC 3.5.4.6) : a viable route for the preparation of 5 '-substituted inosine derivatives
P. CiuffredaPrimo
;E. SantanielloUltimo
2002
Abstract
Adenosine deaminase (ADA) catalyzes the deamination of 2',3'-isopropylidene adenosine and the corresponding 5'-amino derivative in a 3% dimethylsulfoxide aqueous solution. Whereas ADA is unable to convert other 5'-substituted derivatives (acetate, acetamido, azide), the enzyme adenylate deaminase (AMPDA) accepts all the above compounds as substrates for their biotransformation to the corresponding 5'-substituted inosine derivativesPubblicazioni consigliate
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