Celiac disease (CD) is an autoimmune pathology of the small intestine triggered, in genetically predisposed patients, by the exposition to gliadin, a flour protein, thus evoking local immune reactions and mucosal atrophy. The discovery that type 2 transglutaminase (TG2) is the main, if not the sole, target of the endomysium CD-specific autoantibodies assigned to this enzyme a master regulator role of CD. Two separated events, both based on the finding that gliadin is able to act as a TG2 substrate, have been described to indicate that TG2 is involved in both the humoral and cellular immune responses. In this paper we review the novel insights on the localization and enzymatic activity of TG2 in the small intestinal mucosa. Moreover, we report on the capability of gliadin and its peptides to act as TG2 substrates.

Transglutaminase 2 in celiac disease : minireview article / I. Caputo, A. D'Amato, R. Troncone, S. Auricchio, C. Esposito. - In: AMINO ACIDS. - ISSN 0939-4451. - 26:4(2004), pp. 381-386. ((Intervento presentato al 8. convegno International Congress on Amino Acids and Proteins tenutosi a Roma nel 2003 [10.1007/s00726-004-0083-7].

Transglutaminase 2 in celiac disease : minireview article

A. D'Amato;
2004

Abstract

Celiac disease (CD) is an autoimmune pathology of the small intestine triggered, in genetically predisposed patients, by the exposition to gliadin, a flour protein, thus evoking local immune reactions and mucosal atrophy. The discovery that type 2 transglutaminase (TG2) is the main, if not the sole, target of the endomysium CD-specific autoantibodies assigned to this enzyme a master regulator role of CD. Two separated events, both based on the finding that gliadin is able to act as a TG2 substrate, have been described to indicate that TG2 is involved in both the humoral and cellular immune responses. In this paper we review the novel insights on the localization and enzymatic activity of TG2 in the small intestinal mucosa. Moreover, we report on the capability of gliadin and its peptides to act as TG2 substrates.
Celiac disease; Enterocytes; Gluten; Transglutaminase 2; Biochemistry; Clinical Biochemistry; Organic Chemistry
Settore BIO/10 - Biochimica
2004
Article (author)
File in questo prodotto:
File Dimensione Formato  
10.1007_s00726-004-0083-7.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 68.31 kB
Formato Adobe PDF
68.31 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/547339
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 20
  • ???jsp.display-item.citation.isi??? 14
social impact