Over the past decade, epigenetics has emerged as a new layer of regulation of gene expression. Several investigations demonstrated that nutrition and lifestyle regulate lipid metabolism by influencing epigenomic remodeling. Studies on animal models highlighted the role of epigenome modifiers in specific metabolic contexts and established clear links between dysregulation of epigenetic mechanisms and metabolic dysfunction. The relevance of findings in animal models has been translated to humans, as epigenome-wide association studies (EWAS) deeply investigated the relationship between lifestyle and epigenetics in human populations. In this review, we will provide an outlook of recent studies addressing the link between epigenetics and lipid metabolism, by comparing results obtained in animal models and in human subjects.

Of mice and humans through the looking glass: "reflections" on epigenetics of lipid metabolism / R. Longo, A. Ferrari, M. Zocchi, M. Crestani. - In: MOLECULAR ASPECTS OF MEDICINE. - ISSN 0098-2997. - 54(2017 Apr 01), pp. 16-27. [10.1016/j.mam.2017.01.005]

Of mice and humans through the looking glass: "reflections" on epigenetics of lipid metabolism

R. Longo
Primo
;
A. Ferrari
Secondo
;
M. Zocchi
Penultimo
;
M. Crestani
Ultimo
2017-04-01

Abstract

Over the past decade, epigenetics has emerged as a new layer of regulation of gene expression. Several investigations demonstrated that nutrition and lifestyle regulate lipid metabolism by influencing epigenomic remodeling. Studies on animal models highlighted the role of epigenome modifiers in specific metabolic contexts and established clear links between dysregulation of epigenetic mechanisms and metabolic dysfunction. The relevance of findings in animal models has been translated to humans, as epigenome-wide association studies (EWAS) deeply investigated the relationship between lifestyle and epigenetics in human populations. In this review, we will provide an outlook of recent studies addressing the link between epigenetics and lipid metabolism, by comparing results obtained in animal models and in human subjects.
chromatin; epigenetics; Histones; lipid metabolism; non-coding RNA; nutrition; biochemistry; molecular medicine; molecular biology; clinical biochemistry
Settore BIO/10 - Biochimica
Article (author)
File in questo prodotto:
File Dimensione Formato  
63) MAM.pdf

accesso aperto

Descrizione: Versione accettata dall'editore
Tipologia: Pre-print (manoscritto inviato all'editore)
Dimensione 1.56 MB
Formato Adobe PDF
1.56 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/546206
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 1
social impact