Aim and patients: The aim of the present study is to evaluate the additional value of systolic wall thickening to myocardial perfusion in diagnosing myocardial stunning in patients with angiography proven coronary artery disease. We selected 91 ischemic patients (82 males; mean age 59.7 ± 10.3) with CAD documented by angiography. Ischemia was defined as a summed difference score ≥5. All patients underwent a 2-day gated perfusion SPECT protocol. The patients received a dose of 740 MBq of99mTc-tetrofosmin after stress and at rest. Treadmill maximal exercise tests were performed on all patients.Results: The post-stress LVEF was significantly lower than rest LVEF (48.1% ± 10.3% vs 50.3% ± 10.7%; P = .0001). The wall thickening summed difference score was 4.44 ± 4.13 (P = .0001). At a multivariate regression analysis, only WT-SDS as independent variable was significantly correlated with myocardial ischemia (SDS). We also divided patients according to SDS in those with mild (SDS < 8) and severe (SDS ≥ 8) ischemia. WT-SDS, but not ∆LVEF, was significantly different between groups. Conclusions: WT-SDS, more than the depression in the global function (∆LVEF) of the left ventricle, correlates with the degree of ischemia and better identifies, when present, the stunning phenomenon.

Additional value of systolic wall thickening in myocardial stunning evaluated by stress-rest gated perfusion SPECT / A. Bestetti, B. Cuko, A. Decarli, A. Galli, F. Lombardi. - In: JOURNAL OF NUCLEAR CARDIOLOGY. - ISSN 1071-3581. - (2017). [Epub ahead of print]

Additional value of systolic wall thickening in myocardial stunning evaluated by stress-rest gated perfusion SPECT

A. Bestetti
;
B. Cuko
;
A. Decarli
;
A. Galli
;
F. Lombardi
2017

Abstract

Aim and patients: The aim of the present study is to evaluate the additional value of systolic wall thickening to myocardial perfusion in diagnosing myocardial stunning in patients with angiography proven coronary artery disease. We selected 91 ischemic patients (82 males; mean age 59.7 ± 10.3) with CAD documented by angiography. Ischemia was defined as a summed difference score ≥5. All patients underwent a 2-day gated perfusion SPECT protocol. The patients received a dose of 740 MBq of99mTc-tetrofosmin after stress and at rest. Treadmill maximal exercise tests were performed on all patients.Results: The post-stress LVEF was significantly lower than rest LVEF (48.1% ± 10.3% vs 50.3% ± 10.7%; P = .0001). The wall thickening summed difference score was 4.44 ± 4.13 (P = .0001). At a multivariate regression analysis, only WT-SDS as independent variable was significantly correlated with myocardial ischemia (SDS). We also divided patients according to SDS in those with mild (SDS < 8) and severe (SDS ≥ 8) ischemia. WT-SDS, but not ∆LVEF, was significantly different between groups. Conclusions: WT-SDS, more than the depression in the global function (∆LVEF) of the left ventricle, correlates with the degree of ischemia and better identifies, when present, the stunning phenomenon.
cardiac single-photon emission computed tomography; Coronary artery disease; ischemic heart disease; myocardial stunning; Radiology, Nuclear Medicine and Imaging; Cardiology and Cardiovascular Medicine
Settore MED/36 - Diagnostica per Immagini e Radioterapia
8-nov-2017
Article (author)
File in questo prodotto:
File Dimensione Formato  
10.1007%2Fs12350-017-1115-5.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 5.59 MB
Formato Adobe PDF
5.59 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/545617
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 8
social impact