Background and Aim: Variceal bleeding carries a high-mortality rate in patients with liver cirrhosis. Since coagulation and fibrinolysis are abnormal in these patients we evaluated whether or not abnormalities of these haemostasis systems were independently related to mortality. Methods: Global coagulation, coagulation activation and fibrinolysis measurements were performed in 43 cirrhotics bleeding from esophageal varices at baseline and during follow-up and in 43 non-bleeding cirrhotic patients at baseline only. Results: Baseline measurements of coagulation activation and fibrinolysis were more impaired in bleeders. In bleeders, prothrombin time, tissue type plasminogen activator antigen and d-dimer plasma levels were persistently more abnormal in patients who died. High-d-dimer, infection, Child-Pugh C class and MELD score ≥17 were the significant predictors of death at univariate analysis. Two different multivariate analyses to assess the independent prognostic value of these variables, one including the Child-Pugh class, the other including MELD, were performed. Independent predictors of death were high-d-dimer and infection, but not Child-Pugh class, in the former; MELD and infection, but not d-dimer, in the latter. Conclusions: Beside infection, high-d-dimer is a stronger predictor of death as compared to Child-Pugh C class, but not to a MELD score ≥17.

High-D-Dimer plasma levels predict poor outcome in esophageal variceal bleeding / M. Primignani, A. Dell'Era, P. Bucciarelli, B. Bottasso, M.T. Bajetta, R. de Franchis, M. Cattaneo. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 40:11(2008 Nov), pp. 874-881.

High-D-Dimer plasma levels predict poor outcome in esophageal variceal bleeding

A. Dell'Era
Secondo
;
P. Bucciarelli;B. Bottasso;R. de Franchis
Penultimo
;
M. Cattaneo
Ultimo
2008

Abstract

Background and Aim: Variceal bleeding carries a high-mortality rate in patients with liver cirrhosis. Since coagulation and fibrinolysis are abnormal in these patients we evaluated whether or not abnormalities of these haemostasis systems were independently related to mortality. Methods: Global coagulation, coagulation activation and fibrinolysis measurements were performed in 43 cirrhotics bleeding from esophageal varices at baseline and during follow-up and in 43 non-bleeding cirrhotic patients at baseline only. Results: Baseline measurements of coagulation activation and fibrinolysis were more impaired in bleeders. In bleeders, prothrombin time, tissue type plasminogen activator antigen and d-dimer plasma levels were persistently more abnormal in patients who died. High-d-dimer, infection, Child-Pugh C class and MELD score ≥17 were the significant predictors of death at univariate analysis. Two different multivariate analyses to assess the independent prognostic value of these variables, one including the Child-Pugh class, the other including MELD, were performed. Independent predictors of death were high-d-dimer and infection, but not Child-Pugh class, in the former; MELD and infection, but not d-dimer, in the latter. Conclusions: Beside infection, high-d-dimer is a stronger predictor of death as compared to Child-Pugh C class, but not to a MELD score ≥17.
d-Dimer; Liver cirrhosis; Variceal bleeding
Settore MED/12 - Gastroenterologia
Settore MED/09 - Medicina Interna
nov-2008
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/54504
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