Adenosine deaminase from calf intestine catalyzes the stereoselective deamination of (5'S)-5'-methyl-2',3'-isopropylidene adenosine to the corresponding inosine derivative, so that by enzymatic deamination of (5'RS)-5'-methyl-2',3'-isopropylidene adenosine, the diastereomerically pure (5'S)-inosine and the unreacted (5'R)-adenosine derivatives can be efficiently prepared.
Stereoselective deamination of (5 ' RS)-5-methyl-2 ',3 '-isopropylidene adenosine catalyzed by adenosine deaminase: preparation of diastereomerically pure 5 '-methyl adenosine and inosine derivatives / P. Ciuffreda, A. Loseto, E. Santaniello. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 13:3(2002), pp. 239-241. [10.1016/S0957-4166(02)00080-0]
Stereoselective deamination of (5 ' RS)-5-methyl-2 ',3 '-isopropylidene adenosine catalyzed by adenosine deaminase: preparation of diastereomerically pure 5 '-methyl adenosine and inosine derivatives.
P. CiuffredaPrimo
;E. SantanielloUltimo
2002
Abstract
Adenosine deaminase from calf intestine catalyzes the stereoselective deamination of (5'S)-5'-methyl-2',3'-isopropylidene adenosine to the corresponding inosine derivative, so that by enzymatic deamination of (5'RS)-5'-methyl-2',3'-isopropylidene adenosine, the diastereomerically pure (5'S)-inosine and the unreacted (5'R)-adenosine derivatives can be efficiently prepared.Pubblicazioni consigliate
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