A dynamic equilibrium between proliferation and programmed cell death (PCD) of auto-reactive T lymphocytes plays a pivotal role in the prevention of autoimmune diseases. We analyzed T lymphocytes myelin basic protein (MBP)-specific PCD and proliferation in demyelinating diseases. Results showed that MBP-specific PCD was significantly decreased in CD4+ and CD8+ T lymphocytes of progressive multifocal leukoencephalopathy (PML), not determined leukoencephalopathy (NDLE), and acute MS (AMS) patients compared to patients with stable MS (SMS) and healthy controls. MBP-specific proliferation/PCD rates were high in CD4+ T lymphocytes of PML, NDLE, and AMS patients, and in CD8+ T cells of PML and AMS individuals alone. Alterations of the balance between MBP-specific proliferation and PCD are present in demyelinating diseases and could play a major role in the pathogenesis of these diseases.
|Titolo:||Myelin basic protein-specific T lymphocytes proliferation and programmed cell death in demyelinating diseases|
|Autori interni:||FERRANTE, PASQUALE (Penultimo)|
CLERICI, MARIO SALVATORE (Ultimo)
|Parole Chiave:||Apoptosis; Demyelinating diseases; Multiple sclerosis; Myelin basic protein; PCD|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
Settore MED/07 - Microbiologia e Microbiologia Clinica
|Data di pubblicazione:||dic-2008|
|Digital Object Identifier (DOI):||10.1016/j.clim.2008.08.010|
|Appare nelle tipologie:||01 - Articolo su periodico|
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