A novel tool for predicting extracapsular extension during graded partial nerve sparing in radical prostatectomy

Objectives To create a statistical tool for the estimation of extracapsular extension (ECE) level of prostate cancer and determine the nerve-sparing (NS) approach that can be safely performed during radical prostatectomy (RP). Patients and Methods A total of 11 794 lobes, from 6 360 patients who underwent rob ot- assisted RP between 2008 and 2016 we re evaluated. Clin icopatholog ical features we re included in a statistical algorithm for the prediction of the maximum ECE width. Five multivariable logistic models were estimated for: presence of ECE and ECE width of >1, >2, >3, and >4mm.Afive-zone decision rule bas ed on a lower and upper threshold is proposed. Using a graphical interface, surgeons can view patient’spre-treatment characteristics and a curve showing the estim ated probabilities for ECE amount together with the areas identified by the decision rule. Results Of the 6 360 patients, 1 803 (28.4%) were affected by non-organ-confined disease. ECE was present in 1 351 lobes (11.4%) and extended beyond the capsule for >1, >2, >3, and >4 mm in 498 (4.2%), 261 (2.2%), 148 (1.3%), 99 (0.8%) cases, respectively. ECE width was up to 15 mm (interquartile range 1.00–2.00). The five logistic models showed good predictive performance, the area under the receiver operating characteristic curve was: 0.81 for ECE, and 0.84, 0.85, 0.88, and 0.90 for ECE width of >1, >2, >3, and >4 mm, respectively. Conclusion This novel tool predicts w ith good accuracy the presence and amount of ECE. Furthermore, the graphical interface available at www.prece.it can support surgeons in patient counselling and preoperative planning.