The biological activities of a protein isolate from lupin (Lupinus albus) were studied in a rabbit model of atherosclerosis. Focal plaque development was induced at both common carotid arteries by perivascular injury. After surgery. animals were fed three different diets for 90d, all with 1% cholesterol. 15 % SFA and 20 % protein: the protein source was casein (CAS), lupin proteins (LUP) or 50 % CAS + 50 % LUP (CAS + LUP). Lower cholesterolaemia was detected in the LUP v. the CAS group at 60 and 90 d of treatment (- 40.3 and - 33-5 %, respectively; P<0-05). Cryosection analyses of the carotids indicated a significant reduction in focal lesion progression in the LUP v. the CAS group (-37.4%; P<0.05). In summary. in a rabbit model of atherosclerosis. a protein isolate from L. albus reduced cholesterolaemia and exerted a remarkable protective activity against atherosclerosis progression.

Hypolipidaemic and anti-atherosclerotic effects of lupin proteins in a rabbit model / M. Marchesi, C. Parolini, E. Diani, E. Rigamonti, L. Cornelli, A. Arnoldi, C. Sirtori, G. Chiesa. - In: BRITISH JOURNAL OF NUTRITION. - ISSN 0007-1145. - 100:4(2008), pp. 707-710.

Hypolipidaemic and anti-atherosclerotic effects of lupin proteins in a rabbit model

M. Marchesi
Primo
;
C. Parolini
Secondo
;
E. Diani;E. Rigamonti;A. Arnoldi;C. Sirtori
Penultimo
;
G. Chiesa
Ultimo
2008

Abstract

The biological activities of a protein isolate from lupin (Lupinus albus) were studied in a rabbit model of atherosclerosis. Focal plaque development was induced at both common carotid arteries by perivascular injury. After surgery. animals were fed three different diets for 90d, all with 1% cholesterol. 15 % SFA and 20 % protein: the protein source was casein (CAS), lupin proteins (LUP) or 50 % CAS + 50 % LUP (CAS + LUP). Lower cholesterolaemia was detected in the LUP v. the CAS group at 60 and 90 d of treatment (- 40.3 and - 33-5 %, respectively; P<0-05). Cryosection analyses of the carotids indicated a significant reduction in focal lesion progression in the LUP v. the CAS group (-37.4%; P<0.05). In summary. in a rabbit model of atherosclerosis. a protein isolate from L. albus reduced cholesterolaemia and exerted a remarkable protective activity against atherosclerosis progression.
Atherosclerosis; Cholesterol; Lupinus albus; Protein isolates; Rabbits
Settore CHIM/10 - Chimica degli Alimenti
Settore BIO/14 - Farmacologia
2008
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/53969
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