The biological activities of a protein isolate from lupin (Lupinus albus) were studied in a rabbit model of atherosclerosis. Focal plaque development was induced at both common carotid arteries by perivascular injury. After surgery. animals were fed three different diets for 90d, all with 1% cholesterol. 15 % SFA and 20 % protein: the protein source was casein (CAS), lupin proteins (LUP) or 50 % CAS + 50 % LUP (CAS + LUP). Lower cholesterolaemia was detected in the LUP v. the CAS group at 60 and 90 d of treatment (- 40.3 and - 33-5 %, respectively; P<0-05). Cryosection analyses of the carotids indicated a significant reduction in focal lesion progression in the LUP v. the CAS group (-37.4%; P<0.05). In summary. in a rabbit model of atherosclerosis. a protein isolate from L. albus reduced cholesterolaemia and exerted a remarkable protective activity against atherosclerosis progression.
Hypolipidaemic and anti-atherosclerotic effects of lupin proteins in a rabbit model / M. Marchesi, C. Parolini, E. Diani, E. Rigamonti, L. Cornelli, A. Arnoldi, C. Sirtori, G. Chiesa. - In: BRITISH JOURNAL OF NUTRITION. - ISSN 0007-1145. - 100:4(2008), pp. 707-710.
|Titolo:||Hypolipidaemic and anti-atherosclerotic effects of lupin proteins in a rabbit model|
MARCHESI, MARTA (Primo)
PAROLINI, CINZIA (Secondo)
SIRTORI, CESARE (Penultimo)
CHIESA, GIULIA MARIA (Ultimo)
|Parole Chiave:||Atherosclerosis; Cholesterol; Lupinus albus; Protein isolates; Rabbits|
|Settore Scientifico Disciplinare:||Settore CHIM/10 - Chimica degli Alimenti|
Settore BIO/14 - Farmacologia
|Data di pubblicazione:||2008|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1017/S000711450894215X|
|Appare nelle tipologie:||01 - Articolo su periodico|