Adult rats were treated subcutaneously for 10 days with capsaicin, and their food intake and body weight were recorded for almost 6 weeks after stopping the treatment. The animals were exposed to different ambient temperatures: Ta (22, 32, 35, 10 and 22°C). In the capsaicin-treated group a persistent increase in food intake and a reduction of body weight were observed when the animals were exposed to the lowest T a of 10°C. Starting from this temperature, food intake remained significantly higher than in controls until the end of the experiment at a Ta of 22°C. The discrepancy between body weight increase and food intake especially at low temperature (10°C) suggests that capsaicin could prevent suppression of food intake through the mediation of capsaicin-sensitive vagal afferent fibers by activation of cold-temperature-sensitive receptors.
|Titolo:||Rats desensitized by capsaicin alter their food intake regulation especially at cold ambient temperature|
|Autori interni:||FERRERO, MARIA ELENA|
FALCHI, MARIO (Ultimo)
FERRARA, FRANCA (Penultimo)
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
Settore BIO/14 - Farmacologia
|Data di pubblicazione:||2005|
|Appare nelle tipologie:||01 - Articolo su periodico|
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