Adult rats were treated subcutaneously for 10 days with capsaicin, and their food intake and body weight were recorded for almost 6 weeks after stopping the treatment. The animals were exposed to different ambient temperatures: Ta (22, 32, 35, 10 and 22°C). In the capsaicin-treated group a persistent increase in food intake and a reduction of body weight were observed when the animals were exposed to the lowest T a of 10°C. Starting from this temperature, food intake remained significantly higher than in controls until the end of the experiment at a Ta of 22°C. The discrepancy between body weight increase and food intake especially at low temperature (10°C) suggests that capsaicin could prevent suppression of food intake through the mediation of capsaicin-sensitive vagal afferent fibers by activation of cold-temperature-sensitive receptors.
Rats desensitized by capsaicin alter their food intake regulation especially at cold ambient temperature / B. Dib, M. Duvareille, C. Gharib, M.E. Ferrero, A. Fulgenzi, F. Ferrara, M. Falchi. - In: DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH. - ISSN 0378-6501. - 31:2(2005), pp. 53-58.
Rats desensitized by capsaicin alter their food intake regulation especially at cold ambient temperature
M.E. Ferrero;A. Fulgenzi;F. FerraraPenultimo
;M. FalchiUltimo
2005
Abstract
Adult rats were treated subcutaneously for 10 days with capsaicin, and their food intake and body weight were recorded for almost 6 weeks after stopping the treatment. The animals were exposed to different ambient temperatures: Ta (22, 32, 35, 10 and 22°C). In the capsaicin-treated group a persistent increase in food intake and a reduction of body weight were observed when the animals were exposed to the lowest T a of 10°C. Starting from this temperature, food intake remained significantly higher than in controls until the end of the experiment at a Ta of 22°C. The discrepancy between body weight increase and food intake especially at low temperature (10°C) suggests that capsaicin could prevent suppression of food intake through the mediation of capsaicin-sensitive vagal afferent fibers by activation of cold-temperature-sensitive receptors.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.