[186gRe]Re-HEDP is a radiopharmaceutical used for pain palliation in bone metastases from various primary tumors. The negatron emitter with <Eβ> = 357 keV 186gRe is suitable to irradiate cancer and inflammatory cells, but it needs labeling bis-phosphonates as vectors to reach target tissue. Paper radiochromatography was used to evaluate the radiochemical purity of [186gRe]Re-HEDP in radiopharmaceutical solution as well as in biological samples (serum and urine) from treated patients, in order to follow bone-targeting and excretion. Following the activity concentration in each sample vs. time it is effective to elaborate a bio-kinetic model of the radiopharmaceutical and to optimize administration protocols.

Paper radiochromatography for evaluation of radiochemical purity and stability of [186gRe]Re- HEDP in biological samples after human administration / S. Ridone, M.L. Bonardi, F. Groppi, A. Martinotti, Z.B. Alfassi. - In: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY. - ISSN 0236-5731. - 277:1(2008 Jul), pp. 117-123.

Paper radiochromatography for evaluation of radiochemical purity and stability of [186gRe]Re- HEDP in biological samples after human administration

S. Ridone
Primo
;
M.L. Bonardi
Secondo
;
F. Groppi;A. Martinotti
Penultimo
;
2008-07

Abstract

[186gRe]Re-HEDP is a radiopharmaceutical used for pain palliation in bone metastases from various primary tumors. The negatron emitter with = 357 keV 186gRe is suitable to irradiate cancer and inflammatory cells, but it needs labeling bis-phosphonates as vectors to reach target tissue. Paper radiochromatography was used to evaluate the radiochemical purity of [186gRe]Re-HEDP in radiopharmaceutical solution as well as in biological samples (serum and urine) from treated patients, in order to follow bone-targeting and excretion. Following the activity concentration in each sample vs. time it is effective to elaborate a bio-kinetic model of the radiopharmaceutical and to optimize administration protocols.
[186gRe]Re-HEDP ; radiopharmaceuticals ; pain palliation ; metabolic radiotherapy ; bio-kinetic model
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Settore CHIM/03 - Chimica Generale e Inorganica
http://www.springerlink.com.pros.lib.unimi.it/content/8t5k51505v221103/fulltext.pdf
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/53650
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