Astatine-211 (T1/2 = 7.214 h) is an α-emitter at secular equilibrium by EC with its ultra-short-lived α-emitting daughter, polonium-211g(T1/2 = 0.516 s), with a high Linear Energy Transfer (LET – 130 eV.nm–1) and a half-life suitable for metabolic radiotherapy; the overall α branching of the 211At/211gPo system is 100%. The direct production of 209Bi(α,2n)211At/211gPo seems the most satisfactory method; Bi targets were irradiated at JRC-Ispra Cyclotron of European Commission, EC, using α-energy higher than 28.61 MeV in order to produce, via 209Bi(α,3n)reaction, small amounts of the γ-emitter 210At (used as internal spike).
Cyclotron production of 211At/211gPo by 209Bi(alpha,2n) reaction / S. Morzenti, M.L. Bonardi, F. Groppi, C. Zona, E. Persico, E. Menapace, Z.B. Alfassi. - In: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY. - ISSN 0236-5731. - 276:3(2008 Jun), pp. 843-847.
Cyclotron production of 211At/211gPo by 209Bi(alpha,2n) reaction
S. MorzentiPrimo
;M.L. BonardiSecondo
;F. Groppi;C. Zona;E. Persico;
2008
Abstract
Astatine-211 (T1/2 = 7.214 h) is an α-emitter at secular equilibrium by EC with its ultra-short-lived α-emitting daughter, polonium-211g(T1/2 = 0.516 s), with a high Linear Energy Transfer (LET – 130 eV.nm–1) and a half-life suitable for metabolic radiotherapy; the overall α branching of the 211At/211gPo system is 100%. The direct production of 209Bi(α,2n)211At/211gPo seems the most satisfactory method; Bi targets were irradiated at JRC-Ispra Cyclotron of European Commission, EC, using α-energy higher than 28.61 MeV in order to produce, via 209Bi(α,3n)reaction, small amounts of the γ-emitter 210At (used as internal spike).
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