Astatine-211 (T1/2 = 7.214 h) is an α-emitter at secular equilibrium by EC with its ultra-short-lived α-emitting daughter, polonium-211g(T1/2 = 0.516 s), with a high Linear Energy Transfer (LET – 130 eV.nm–1) and a half-life suitable for metabolic radiotherapy; the overall α branching of the 211At/211gPo system is 100%. The direct production of 209Bi(α,2n)211At/211gPo seems the most satisfactory method; Bi targets were irradiated at JRC-Ispra Cyclotron of European Commission, EC, using α-energy higher than 28.61 MeV in order to produce, via 209Bi(α,3n)reaction, small amounts of the γ-emitter 210At (used as internal spike).

Cyclotron production of 211At/211gPo by 209Bi(alpha,2n) reaction / S. Morzenti, M.L. Bonardi, F. Groppi, C. Zona, E. Persico, E. Menapace, Z.B. Alfassi. - In: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY. - ISSN 0236-5731. - 276:3(2008 Jun), pp. 843-847.

Cyclotron production of 211At/211gPo by 209Bi(alpha,2n) reaction

S. Morzenti
Primo
;
M.L. Bonardi
Secondo
;
F. Groppi;C. Zona;E. Persico;
2008-06

Abstract

Astatine-211 (T1/2 = 7.214 h) is an α-emitter at secular equilibrium by EC with its ultra-short-lived α-emitting daughter, polonium-211g(T1/2 = 0.516 s), with a high Linear Energy Transfer (LET – 130 eV.nm–1) and a half-life suitable for metabolic radiotherapy; the overall α branching of the 211At/211gPo system is 100%. The direct production of 209Bi(α,2n)211At/211gPo seems the most satisfactory method; Bi targets were irradiated at JRC-Ispra Cyclotron of European Commission, EC, using α-energy higher than 28.61 MeV in order to produce, via 209Bi(α,3n)reaction, small amounts of the γ-emitter 210At (used as internal spike).
astatine-211 ; alpha emitter ; metabolic radiotherapy
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Settore CHIM/03 - Chimica Generale e Inorganica
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/53645
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 13
  • ???jsp.display-item.citation.isi??? 13
social impact