Hepatocellular carcinoma (HCC) frequently complicates hepatic cirrhosis secondary to viral infection or iron overload. Therefore, patients affected by thalassaemia syndromes have a theoretically high risk of developing the tumour. We collected data on patients attending Italian centres for the treatment of thalassaemia. Twenty-two cases of HCC were identified; 15 were male. At diagnosis, the mean age was 45 ± 11 years and the mean serum ferritin was 1764 ± 1448 μg/l. Eighty-six percent had been infected by hepatitis C virus. Nineteen of 22 cases were diagnosed after 1993, suggesting that this problem is becoming more frequent with the aging population of thalassaemia patients.
|Titolo:||Hepatocellular carcinoma in the thalassaemia syndromes|
|Parole Chiave:||Cirrhosis; Hepatitis C; Hepatocellular carcinoma; Iron overload; Thalassaemia|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||gen-2004|
|Digital Object Identifier (DOI):||10.1046/j.1365-2141.2003.04732.x|
|Appare nelle tipologie:||01 - Articolo su periodico|