Anti-phospholipid antibodies (aPL) are one of the most recent examples of autoantibodies that can appear even long time before any clinical manifestation can be associated with them. There is a general agreement that they may represent a strong risk factor for recurrent thrombosis and/or fetal losses. Anti-phospholipid antibodies represent a necessary but not sufficient factor (first hit) for thrombosis, and require additional triggering factors (second hit) to disclose the thrombogenic activity. Several factors may affect the predictive value of aPL, including titre, immunoglobulin isotype, fine antigenic specificity and affinity binding activity. Their careful evaluation is suggested in order to characterize the true predictive value of aPL.
|Titolo:||Predictive, protective, orphan autoantibodies : the example of anti-phospholipid antibodies|
MERONI, PIERLUIGI (Primo)
|Parole Chiave:||Anti-phospholipid antibodies; Autoantibodies; Predictive value|
|Settore Scientifico Disciplinare:||Settore MED/16 - Reumatologia|
|Data di pubblicazione:||set-2008|
|Digital Object Identifier (DOI):||10.1016/j.autrev.2008.08.001|
|Appare nelle tipologie:||01 - Articolo su periodico|