Microglia are resident myeloid cells of the central nervous system (CNS) that are maintained by self-renewal and actively participate in tissue homeostasis and immune defense. Under the influence of endogenous or pathological signals, microglia undertake biochemical transformations that are schematically classified as the pro-inflammatory M1 phenotype and the alternatively activated M2 state. Dysregulated proliferation of M1-activated microglia has detrimental effects, while an increased number of microglia with the alternative, pro-resolving phenotype might be beneficial in brain pathologies; however, the proliferative response of microglia to M2 signals is not yet known. We thus evaluated the ability of interleukin-4 (IL-4), a typical M2 and proliferative signal for peripheral macrophages, to induce microglia proliferation and compared it with other proliferative and M2 polarizing stimuli for macrophages, namely colony-stimulating factor-1 (CSF-1) and the estrogen hormone, 17β-estradiol (E2).

Selective proliferative response of microglia to alternative polarization signals / G. Pepe, M. De Maglie, L. Minoli, A. Villa, A. Maggi, E. Vegeto. - In: JOURNAL OF NEUROINFLAMMATION. - ISSN 1742-2094. - 14:1(2017 Dec 04).

Selective proliferative response of microglia to alternative polarization signals

G. Pepe
Primo
;
M. De Maglie
Secondo
;
L. Minoli;A. Villa;A. Maggi
Penultimo
;
E. Vegeto
Ultimo
2017-12-04

Abstract

Microglia are resident myeloid cells of the central nervous system (CNS) that are maintained by self-renewal and actively participate in tissue homeostasis and immune defense. Under the influence of endogenous or pathological signals, microglia undertake biochemical transformations that are schematically classified as the pro-inflammatory M1 phenotype and the alternatively activated M2 state. Dysregulated proliferation of M1-activated microglia has detrimental effects, while an increased number of microglia with the alternative, pro-resolving phenotype might be beneficial in brain pathologies; however, the proliferative response of microglia to M2 signals is not yet known. We thus evaluated the ability of interleukin-4 (IL-4), a typical M2 and proliferative signal for peripheral macrophages, to induce microglia proliferation and compared it with other proliferative and M2 polarizing stimuli for macrophages, namely colony-stimulating factor-1 (CSF-1) and the estrogen hormone, 17β-estradiol (E2).
estrogen; interleukin-4; microglia; proliferation
Settore BIO/14 - Farmacologia
Imaging of Neuroinflammation in Neurodegenerative Diseases
Centro Interdipartimentale di Eccellenza per le Malattie Neurodegenerative CEND
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/533901
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