The profound scientific and commercial success of molecular biology, the progress of 'cancer gene' investigation technologies, together, pushed forward the postulate that genes explain 'everything'. Yet, during the last few years the microenvironments of solid tumors have emerged as key modulators of initiation, progression and metastasis and as essential to the therapeutic response. In the present review, we provide a synthetic examination of the main traits of cells embedded into the cancer stroma and emphasize several evidences that all components of the tumor tissue cooperate in space and time. Then we turn to discuss the epitheliocentric somatic mutational view and other new paradigms assuming that disturbed tissue interactions among cell populations are critical to cancer causation, growth and spread.

Cancer as a changed tissue's way of life (when to treat, when to watch and when to think) / R. Demicheli, D.F.T. Quiton, M. Fornili, W.J.M. Hrushesky. - In: FUTURE ONCOLOGY. - ISSN 1479-6694. - 12:5(2016 Mar), pp. 647-657. [10.2217/fon.15.336]

Cancer as a changed tissue's way of life (when to treat, when to watch and when to think)

M. Fornili;
2016-03

Abstract

The profound scientific and commercial success of molecular biology, the progress of 'cancer gene' investigation technologies, together, pushed forward the postulate that genes explain 'everything'. Yet, during the last few years the microenvironments of solid tumors have emerged as key modulators of initiation, progression and metastasis and as essential to the therapeutic response. In the present review, we provide a synthetic examination of the main traits of cells embedded into the cancer stroma and emphasize several evidences that all components of the tumor tissue cooperate in space and time. Then we turn to discuss the epitheliocentric somatic mutational view and other new paradigms assuming that disturbed tissue interactions among cell populations are critical to cancer causation, growth and spread.
cancer attractor; cancer paradigms; somatic mutation theory; tissue regulatory network; tumor-stroma interactions; animals; endothelial cells; fibroblasts; humans; macrophages; neoplasms; neutrophils; time factors; tumor microenvironment; oncology; cancer research
Settore MED/01 - Statistica Medica
Settore MED/06 - Oncologia Medica
FUTURE ONCOLOGY
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/532598
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