Cerebellar ataxias represent a wide and heterogeneous group of diseases characterized by balance and coordination disturbance, dysarthria, dyssynergia and adyadococinesia, caused by a dysfunction in the cerebellum. In recent years there has been growing interest in discovering therapeutical strategy for specific forms of cerebellar ataxia. Together with pharmacological studies, there has been growing interest in non-invasive cerebellar stimulation techniques to improve ataxia and limb coordination. Both transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are non-invasive techniques to modulate cerebro and cerebellar cortex excitability using magnetic or electric fields. Here we aim to review the most relevant studies regarding the application of TMS and tDCS for the treatment of cerebellar ataxia. As pharmacological strategies were shown to be effective in specific forms of cerebellar ataxia and are not devoid of collateral effects, non-invasive stimulation may represent a promising strategy to improve residual cerebellar circuits functioning and a complement tool to pharmacotherapy.

Noninvasive cerebellar stimulation as a complement tool to pharmacotherapy / R. Ferrucci, T. Bocci, F. Cortese, F. Ruggiero, A. Priori. - In: CURRENT NEUROPHARMACOLOGY. - ISSN 1570-159X. - 17:1(2019), pp. 14-20.

Noninvasive cerebellar stimulation as a complement tool to pharmacotherapy

R. Ferrucci
Primo
;
T. Bocci;A. Priori
Ultimo
2019

Abstract

Cerebellar ataxias represent a wide and heterogeneous group of diseases characterized by balance and coordination disturbance, dysarthria, dyssynergia and adyadococinesia, caused by a dysfunction in the cerebellum. In recent years there has been growing interest in discovering therapeutical strategy for specific forms of cerebellar ataxia. Together with pharmacological studies, there has been growing interest in non-invasive cerebellar stimulation techniques to improve ataxia and limb coordination. Both transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are non-invasive techniques to modulate cerebro and cerebellar cortex excitability using magnetic or electric fields. Here we aim to review the most relevant studies regarding the application of TMS and tDCS for the treatment of cerebellar ataxia. As pharmacological strategies were shown to be effective in specific forms of cerebellar ataxia and are not devoid of collateral effects, non-invasive stimulation may represent a promising strategy to improve residual cerebellar circuits functioning and a complement tool to pharmacotherapy.
Ataxia; Cerebellar tDCS; Cerebellar TMS; Cerebellum; Non invasive neuromodulation; tDCS; Animals; Cerebellar Ataxia; Cerebellum; Combined Modality Therapy; Humans; Randomized Controlled Trials as Topic; Transcranial Direct Current Stimulation; Transcranial Magnetic Stimulation
Settore MED/26 - Neurologia
Settore M-PSI/02 - Psicobiologia e Psicologia Fisiologica
2019
14-nov-2017
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/532520
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