The enzymes adenosine deaminase (ADA) and adenylate deaminase (AMPDA) are able to catalyze the hydrolytic dechlorination of 6-chloropurine riboside and the corresponding 2',3'-O-isopropylidene derivative, but show no activity towards the 3,4-O-isopropylidene-1-methylriboside of 6-chloropurine and adenine.
Activity of adenosine deaminase (ADA) and adenylate deaminase (AMPDA) towards 6-chloropurine nucleosides modified in the ribose moiety / P.Ciuffreda, B.Buzzi, L. Alessandrini, E. Santaniello. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 2004:21(2004), pp. 4405-4409. [10.1002/ejoc.200400380]
Activity of adenosine deaminase (ADA) and adenylate deaminase (AMPDA) towards 6-chloropurine nucleosides modified in the ribose moiety
P.CiuffredaPrimo
;B.BuzziSecondo
;L. AlessandriniPenultimo
;E. SantanielloUltimo
2004
Abstract
The enzymes adenosine deaminase (ADA) and adenylate deaminase (AMPDA) are able to catalyze the hydrolytic dechlorination of 6-chloropurine riboside and the corresponding 2',3'-O-isopropylidene derivative, but show no activity towards the 3,4-O-isopropylidene-1-methylriboside of 6-chloropurine and adenine.
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