Small-diameter nervefibers, which subserve nociception, can be affected early in peripheral neuropathies, although their injury may not be detectable by routine neurophysiologic tests. On the other hand, skin biopsy has proved to be a reliable tool to examine nonmyelinated nervefibers, as assessed by the quantification of intra-epidermal nervefiber (IENF) density not only along with the degenerative process but, noteworthy, IENF density could be very helpful in evaluating drug efficacy such as erythropoietin (EPO) treatment.

Intra-epidermal nerve fibers density and nociception in EPO-treated type 1 diabetic rats with peripheral neuropathy / R. Bianchi, R. Lombardi, C. PORRETTA SERAPIGLIA, G. LAURIA PINTER (METHODS IN MOLECULAR BIOLOGY). - In: Tissue-Protective Cytokines : Methods and Protocols / [a cura di] P. Ghezzi, A. Cerami. - [s.l] : Humana Press Inc., 2013. - ISBN 9781627033077. - pp. 197-211

Intra-epidermal nerve fibers density and nociception in EPO-treated type 1 diabetic rats with peripheral neuropathy

C. PORRETTA SERAPIGLIA;G. LAURIA PINTER
2013

Abstract

Small-diameter nervefibers, which subserve nociception, can be affected early in peripheral neuropathies, although their injury may not be detectable by routine neurophysiologic tests. On the other hand, skin biopsy has proved to be a reliable tool to examine nonmyelinated nervefibers, as assessed by the quantification of intra-epidermal nervefiber (IENF) density not only along with the degenerative process but, noteworthy, IENF density could be very helpful in evaluating drug efficacy such as erythropoietin (EPO) treatment.
Diabetes; Diabetic neuropathy; Epidermal nerve fibers; Erythropoietin; PGP 9.5; Skin; Animals; Diabetes Mellitus, Type 1; Erythropoietin; Male; Nerve Fibers; Nociception; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Molecular Biology; Genetics
Settore MED/26 - Neurologia
Book Part (author)
File in questo prodotto:
File Dimensione Formato  
Pagine da Methods in molecular biology-Lauria.pdf

non disponibili

20.66 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/530356
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact