IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca

IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.

AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.

The development of molecular carriers able to carry molecules directly into the cell is an area of intensive research. Cationic nanoparticles are effective delivery systems for several classes of molecules, such as anticancer agents, oligonucleotides and antibodies. Indeed, a cationic charge on the outer surface allows a rapid cellular uptake together with the possibility of carrying negatively charged molecules. In this work, we studied the self-assembly of an ultra-short alpha alpha beta-tripeptide containing an L-Arg-L-Ala sequence and an unnatural fluorine substituted beta(2,3)-diaryl-amino acid. The presence of the unnatural beta(2,3)-diaryl-amino acid allowed us to obtain a protease stable sequence. Furthermore, an arginine guanidinium group triggered the formation of spherical assemblies that were able to load small molecules and enter cells. These spherical architectures, thus, represent interesting candidates for the delivery of exogenous entities directly into cells.

Self-assembly of an amphipathic ααβ-tripeptide into cationic spherical particles for intracellular delivery / R. Bucci, D. Priyadip, I. Filomena, F. Marco, R. Gandolfi, M.L. Gelmi, R. Meital, S. Pellegrino. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 15:32(2017 Jul 21), pp. 6773-6779.

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