Interleukin-1 receptor 8 (IL-1R8, also known as single immunoglobulin IL-1R-related receptor, SIGIRR, or TIR8) is a member of the IL-1 receptor (ILR) family with distinct structural and functional characteristics, acting as a negative regulator of ILR and Toll-like receptor (TLR) downstream signalling pathways and inflammation. Natural killer (NK) cells are innate lymphoid cells which mediate resistance against pathogens and contribute to the activation and orientation of adaptive immune responses. NK cells mediate resistance against haematopoietic neoplasms but are generally considered to play a minor role in solid tumour carcinogenesis. Here we report that IL-1R8 serves as a checkpoint for NK cell maturation and effector function. Its genetic blockade unleashes NK-cell-mediated resistance to hepatic carcinogenesis, haematogenous liver and lung metastasis, and cytomegalovirus infection.
IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity / M. Molgora, E. Bonavita, A. Ponzetta, F. Riva, M. Barbagallo, S. Jaillon, B. Popović, G. Bernardini, E. Magrini, F. Gianni, S. Zelenay, S. Jonjić, A. Santoni, C. Garlanda, A. Mantovani. - In: NATURE. - ISSN 0028-0836. - 551:7678(2017), pp. 110-114.
|Titolo:||IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity|
|Settore Scientifico Disciplinare:||Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria|
Settore VET/05 - Malattie Infettive degli Animali Domestici
|Data di pubblicazione:||2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/nature24293|
|Appare nelle tipologie:||01 - Articolo su periodico|