We investigated in ninety Caucasian pediatric patients the impact of the main polymorphisms occurring in CYP3A, CYP2D6, ABCB1 and ABCG2 genes on second-generation antipsychotics plasma concentrations, and their association with the occurrence of adverse drug reactions. Patients with the CA/AA ABCG2 genotype had a statistically significant lower risperidone plasma concentration/dose ratio (Ct/ds) (P-value: 0.007) and an higher estimated marginal probability of developing metabolism and nutrition disorders as compared to the ABCG2 c.421 non-CA/AA genotypes (P-value: 0.008). Multivariate analysis revealed that the ABCG2 c.421 CA/AA genotype was found associated to a higher hazard (P-value: 0.004) of developing adverse drug reactions classified as metabolism and nutrition disorders. The ABCB1 2677TT/3435TT genotype had a statistically significant lower aripiprazole Ct/ds if compared with patients with others ABCB1 genotypes (P-value: 0.026). Information obtained on ABCB1 and ABCG2 gene variants may result useful to tailor treatments with these drugs in Caucasian pediatric patients.
The predictive value of ABCB1, ABCG2, CYP3A4/5 and CYP2D6 polymorphisms for risperidone and aripiprazole plasma concentrations and the occurrence of adverse drug reactions / C. Rafaniello, M. Sessa, F..F. Bernardi, M. Pozzi, S. Cheli, D. Cattaneo, S. Baldelli, M. Molteni, R. Bernardini, F. Rossi, E. Clementi, C. Bravaccio, S. Radice, A. Capuano. - In: PHARMACOGENOMICS JOURNAL. - ISSN 1470-269X. - 18:3(2018 May 22), pp. 422-430.
|Titolo:||The predictive value of ABCB1, ABCG2, CYP3A4/5 and CYP2D6 polymorphisms for risperidone and aripiprazole plasma concentrations and the occurrence of adverse drug reactions|
RADICE, SONIA (Penultimo)
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||22-mag-2018|
|Data ahead of print / Data di stampa:||18-lug-2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/tpj.2017.38|
|Appare nelle tipologie:||01 - Articolo su periodico|