PURPOSE. To evaluate the outcomes of standard automated perimetry (SAP) in patients with obstructive sleep apnea (OSA). METHODS. Eighty OSA patients and 111 age-matched controls were consecutively and prospectively enrolled. One eye per subject was randomly selected. All participants underwent at least one reliable SAP (24-2 SITA Standard algorithm). The peripapillary retinal nerve fiber layer thickness (RNFL) was measured with spectral-domain optical coherence tomography (OCT). Patients with OSA were classified into three groups according to the apnea/hypopnea index: mild, moderate, or severe OSA. Parameters of SAP and OCT were compared between healthy controls and OSA patients. Correlation of apnea/hypopnea index with OCT and SAP measurements were calculated. RESULTS. Mean age, best-corrected visual acuity, and central corneal thickness were similar between groups. Intraocular pressure, however, was lower in the OSA group. Mean deviation of SAP was -0.23 +/- 0.8 dB in the control group and -1.74 +/- 2.8 dB in the OSA group (P < 0.001). Thickness of RNFL measured with OCT did not differ significantly between groups. Patients with OSA showed reduced sensitivity at most points tested by white-on-white perimetry compared with healthy individuals. The threshold values were more depressed in the peripheral visual field. The apnea/hypopnea index was related to the SAP indices: Pearson correlations were -0.432 with mean deviation, 0.467 with pattern standard deviation, and -0.416 with the visual field index (P < 0.001). CONCLUSIONS. Patients with OSA exhibited reduced retinal sensitivity measured with SAP compared with healthy controls.

Retinal sensitivity is reduced in patients with obstructive sleep apnea / B. Ferrandez, A. Ferreras, P. Calvo, B. Abadia, P. Fogagnolo, Y. Wang, J.M. Marin, M. Iester. - In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. - ISSN 1552-5783. - 55:11(2014 Oct 09), pp. 7119-7125. [10.1167/iovs.14-14389]

Retinal sensitivity is reduced in patients with obstructive sleep apnea

P. Fogagnolo;
2014

Abstract

PURPOSE. To evaluate the outcomes of standard automated perimetry (SAP) in patients with obstructive sleep apnea (OSA). METHODS. Eighty OSA patients and 111 age-matched controls were consecutively and prospectively enrolled. One eye per subject was randomly selected. All participants underwent at least one reliable SAP (24-2 SITA Standard algorithm). The peripapillary retinal nerve fiber layer thickness (RNFL) was measured with spectral-domain optical coherence tomography (OCT). Patients with OSA were classified into three groups according to the apnea/hypopnea index: mild, moderate, or severe OSA. Parameters of SAP and OCT were compared between healthy controls and OSA patients. Correlation of apnea/hypopnea index with OCT and SAP measurements were calculated. RESULTS. Mean age, best-corrected visual acuity, and central corneal thickness were similar between groups. Intraocular pressure, however, was lower in the OSA group. Mean deviation of SAP was -0.23 +/- 0.8 dB in the control group and -1.74 +/- 2.8 dB in the OSA group (P < 0.001). Thickness of RNFL measured with OCT did not differ significantly between groups. Patients with OSA showed reduced sensitivity at most points tested by white-on-white perimetry compared with healthy individuals. The threshold values were more depressed in the peripheral visual field. The apnea/hypopnea index was related to the SAP indices: Pearson correlations were -0.432 with mean deviation, 0.467 with pattern standard deviation, and -0.416 with the visual field index (P < 0.001). CONCLUSIONS. Patients with OSA exhibited reduced retinal sensitivity measured with SAP compared with healthy controls.
obstructive sleep apnea; optic disc; optical coherence tomography; retinal nerve fiber layer; visual field; female; follow-up studies; humans; male; middle aged; optic disk; prospective studies; retinal diseases; retinal ganglion cells; sleep apnea, obstructive; tomography, optical coherence; visual fields
Settore MED/30 - Malattie Apparato Visivo
9-ott-2014
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/528088
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